Rat Kalirin, KALRN ELISA Kit | MyBioSource MBS9337073 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Rat Kalirin, KALRN ELISA Kit

catalog :

MBS9337073

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS9337073

products type :

ELISA Kit

products full name :

Rat Kalirin, KALRN ELISA Kit

products short name :

[kalirin, RhoGEF kinase]

products name syn :

[Rat Kalirin (KALRN) ELISA kit; hCG_2022551; DUET; DUO; FLJ12332; FLJ16443; FLJ18196; FLJ18623; HAPIP; TRAD; huntingtin-associated protein interacting protein (duo) ; serine/threonine kinase with Dbl- and pleckstrin homology domains; kalirin; RhoGEF kinase]

other names :

[kalirin; Kalirin; kalirin; P-CIP10; cyclin B1; protein Duo; PAM COOH-terminal interactor protein 10; huntingtin-associated protein-interacting protein; huntingtin-associated protein interacting protein (duo); serine/threonine kinase with Dbl- and pleckstrin homology domain; serine/threonine-protein kinase with Dbl- and pleckstrin homology domain; kalirin, RhoGEF kinase; Huntingtin-associated protein-interacting protein; PAM COOH-terminal interactor protein 10; P-CIP10; Protein Duo; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain]

products gene name :

[KALRN]

other gene names :

[Kalrn; Kalrn; Duo; Hapip; Kalirin; Duo; Hapip; P-CIP10]

uniprot entry name :

KALRN_RAT

reactivity :

Rat

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 0.5 ng/ml - 16 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of KALRN (hereafter termed "analyte") in undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

295054252

ncbi acc num :

NP_114451.2

ncbi gb acc num :

NM_032062.2

uniprot acc num :

P97924

ncbi mol weight :

336,587 Da

ncbi pathways :

Cell Death Signalling Via NRAGE, NRIF And NADE Pathway (574163); G Alpha (12/13) Signalling Events Pathway (574255); G Alpha (q) Signalling Events Pathway (574254); GPCR Downstream Signaling Pathway (574250); NRAGE Signals Death Through JNK Pathway (574164); Rho GTPase Cycle Pathway (574210); Signal Transduction Pathway (574116); Signaling By GPCR Pathway (574222); Signaling By Rho GTPases Pathway (574209); Signalling By NGF Pathway (574159)

ncbi summary :

binds the human huntingtin associated protein Hap1 in vitro; has GDP/GTP exchange factor activity for Rho subfamily GTP-binding proteins [RGD, Feb 2006]

uniprot summary :

kalirin: a bifunctional enzyme with protein kinase activity and guanine-exchange factor (GEF) activity. A protein kinase of the CAMK group. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Genetic variants are associated with susceptibility to coronary heart disease type 5 (CHDS5), a multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) Interacts with FASLG. The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity. 6 isoforms of the human protein are produced by alternative splicing. Isoform 2 is brain specific and is highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle. Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); GEFs, Rac/Rho; Protein kinase, CAMK; Kinase, protein; GEFs; CAMK group; Trio family. Cellular Component: neuron projection; cytoskeleton; cell soma; perinuclear region of cytoplasm. Molecular Function: protein serine/threonine kinase activity; Rho guanyl-nucleotide exchange factor activity; protein binding; enzyme binding; metal ion binding; guanyl-nucleotide exchange factor activity; ATP binding. Biological Process: nervous system development; axonogenesis; regulation of dendrite development; protein amino acid phosphorylation; positive regulation of GTPase activity

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095