catalog number :
MBS9337046
products type :
ELISA Kit
products full name :
Human Ribonuclease ZC3H12A, ZC3H12A ELISA Kit
products short name :
[zinc finger CCCH-type containing 12A]
products name syn :
[Human Ribonuclease ZC3H12A (ZC3H12A) ELISA kit; FLJ23231; MCPIP; MCPIP1; RP3-423B22.1; dJ423B22.1; MCP induced protein 1; MCP-1 treatment-induced protein; MCP-induced protein 1; OTTHUMP00000004399; zinc finger CCCH-type containing 12A]
other names :
[ribonuclease ZC3H12A; Ribonuclease ZC3H12A; ribonuclease ZC3H12A; MCP induced protein 1; MCP-induced protein 1; MCP-1 treatment-induced protein; zinc finger CCCH domain-containing protein 12A; zinc finger CCCH-type containing 12A; MCP-induced protein 1; Zinc finger CCCH domain-containing protein 12A]
products gene name :
[ZC3H12A]
other gene names :
[ZC3H12A; ZC3H12A; MCPIP; MCPIP1; dJ423B22.1; MCPIP; MCPIP1]
uniprot entry name :
ZC12A_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Human Body Fluids And Tissue Homogenates. Assay Type: Quantitative Sandwich. Detection Range: 31.2pg/ml-1000pg/ml. Sensitivity: 5.0pg/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determine the level of ZBTB10 (hereafter termed "analyte") in undiluted original Human body fluids and tissue homogenates. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_079355.2
ncbi gb acc num :
NM_025079.2
ncbi mol weight :
65,699 Da
ncbi summary :
ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM, Mar 2008]
uniprot summary :
MCPIP1: Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3 -untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA. Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19. Belongs to the ZC3H12 family. Protein type: Hydrolase; EC 3.1.-.-. Chromosomal Location of Human Ortholog: 1p34.3. Cellular Component: nucleoplasm; cytoplasm; plasma membrane. Molecular Function: protein binding; endonuclease activity; metal ion binding. Biological Process: apoptosis; inhibition of NF-kappaB transcription factor; negative regulation of nitric oxide biosynthetic process; negative regulation of interleukin-6 production; positive regulation of fat cell differentiation; angiogenesis; negative regulation of tumor necrosis factor production; cell differentiation; negative regulation of macrophage activation; positive regulation of autophagy
size4 :
10x96-Strip-Wells