Human Exosome complex component RRP46, EXOSC5 ELISA Kit | MyBioSource MBS9336213 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Exosome complex component RRP46, EXOSC5 ELISA Kit

catalog :

MBS9336213

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9336213

products type :

ELISA Kit

products full name :

Human Exosome complex component RRP46, EXOSC5 ELISA Kit

products short name :

[exosome component 5]

products name syn :

[Human Exosome complex component RRP46 (EXOSC5) ELISA kit; MGC111224; MGC12901; RRP41B; RRP46; Rrp46p; hRrp46p; p12B; exosome component Rrp46; exosome component 5]

other names :

[exosome complex component RRP46; Exosome complex component RRP46; exosome complex component RRP46; exosome component Rrp46; exosome complex exonuclease RRP46; ribosomal RNA-processing protein 46; chronic myelogenous leukemia tumor antigen 28; exosome component 5; Chronic myelogenous leukemia tumor antigen 28; Exosome component 5; Ribosomal RNA-processing protein 46; p12B]

products gene name :

[EXOSC5]

other gene names :

[EXOSC5; EXOSC5; p12B; RRP46; RRP41B; Rrp46p; hRrp46p; CML28; RRP46]

uniprot entry name :

EXOS5_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: 1.0 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of EXOSC5 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

47174864

ncbi acc num :

NP_064543.3

ncbi gb acc num :

NM_020158.3

uniprot acc num :

Q9NQT4

ncbi mol weight :

25,249 Da

ncbi pathways :

Activation Of Genes By ATF4 Pathway (530772); Deadenylation-dependent MRNA Decay Pathway (160993); Destabilization Of MRNA By Butyrate Response Factor 1 (BRF1) Pathway (187213); Destabilization Of MRNA By KSRP Pathway (187215); Destabilization Of MRNA By Tristetraprolin (TTP) Pathway (187214); Diabetes Pathways (105902); Disease Pathway (530764); Exosome, Eukaryotes Pathway (413457); Exosome, Eukaryotes Pathway (468397); Gene Expression Pathway (105937)

uniprot summary :

EXOSC5: Non-catalytic component of the RNA exosome complex which has 3 5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. Belongs to the RNase PH family. Protein type: Ribonuclease; Nucleolus; EC 3.1.13.-. Chromosomal Location of Human Ortholog: 19q13.1. Cellular Component: cytoplasm; nucleolus; exosome (RNase complex); cytosol; nucleus. Molecular Function: 3 -5 -exoribonuclease activity; protein binding; exoribonuclease activity; RNA binding. Biological Process: gene expression; DNA deamination; defense response to virus; rRNA processing; mRNA catabolic process, deadenylation-dependent decay

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage