Human Spectrin beta chain, erythrocyte, SPTB ELISA Kit | MyBioSource MBS9335867 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Spectrin beta chain, erythrocyte, SPTB ELISA Kit

catalog :

MBS9335867

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS9335867

products type :

ELISA Kit

products full name :

Human Spectrin beta chain, erythrocyte, SPTB ELISA Kit

products short name :

[spectrin, beta, erythrocytic]

products name syn :

[Human Spectrin beta chain; erythrocyte (SPTB) ELISA kit; EL3; HS2; HSPTB1; SPH2; membrane cytoskeletal protein; spectrin beta; spectrin; beta; erythrocytic]

other names :

[spectrin beta chain, erythrocytic isoform b; Spectrin beta chain, erythrocytic; spectrin beta chain, erythrocytic; beta-I spectrin; membrane cytoskeletal protein; spectrin beta chain, erythrocyte; spectrin, beta, erythrocytic; Beta-I spectrin]

products gene name :

[SPTB]

other gene names :

[SPTB; SPTB; EL3; HS2; SPH2; HSPTB1; SPTB1]

uniprot entry name :

SPTB1_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 3.12ng/ml-100ng/ml. Sensitivity: 1.0ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of SPTB (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

67782319

ncbi acc num :

NP_000338.3

ncbi gb acc num :

NM_000347.5

uniprot acc num :

P11277

ncbi mol weight :

246,468 Da

ncbi pathways :

Axon Guidance Pathway (575211); Axon Guidance Pathway (105688); Developmental Biology Pathway (575210); Developmental Biology Pathway (477129); Interaction Between L1 And Ankyrins Pathway (161005); L1CAM Interactions Pathway (161003); NCAM Signaling For Neurite Out-growth Pathway (105689); NCAM Signaling For Neurite Out-growth Pathway (575220)

ncbi summary :

This locus encodes a member of the spectrin gene family. Spectrin proteins, along with ankyrin, play a role in cell membrane organization and stability. The protein encoded by this locus functions in stability of erythrocyte membranes, and mutations in this gene have been associated with spherocytosis type 2, hereditary elliptocytosis, and neonatal hemolytic anemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]

uniprot summary :

SPTB1: Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Defects in SPTB are the cause of elliptocytosis type 3 (EL3). EL3 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape. Defects in SPTB are the cause of spherocytosis type 2 (SPH2); also known as hereditary spherocytosis type 2 (HS2). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH2 is characterized by severe hemolytic anemia. Inheritance is autosomal dominant. Belongs to the spectrin family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Cytoskeletal; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 14q23-q24.2. Cellular Component: spectrin; cell surface; protein complex; cytoplasm; cytosol; actin cytoskeleton. Molecular Function: actin filament binding; protein binding; structural constituent of cytoskeleton; protein heterodimerization activity; ankyrin binding; actin binding. Biological Process: axon guidance; plasma membrane organization and biogenesis; actin filament capping; hemopoiesis; porphyrin biosynthetic process. Disease: Spherocytosis, Type 2, Included

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095