ELISA/assay

Human Methylcytosine dioxygenase TET1, TET1 ELISA Kit

MBS9335267

48-Strip-Wells

470 USD

ELISA Kit

Human Methylcytosine dioxygenase TET1, TET1 ELISA Kit

[tet oncogene 1]

[Human Methylcytosine dioxygenase TET1 (TET1) ELISA kit; RP11-119F7.1; CXXC6; FLJ10839; FLJ41442; KIAA1676; LCX; bA119F7.1; CXXC finger 6; leukemia-associated protein with a CXXC domain; ten-eleven translocation-1; tet oncogene 1]

[methylcytosine dioxygenase TET1; Methylcytosine dioxygenase TET1; methylcytosine dioxygenase TET1; CXXC finger 6; tet oncogene 1; CXXC zinc finger 6; TET1 splice variant VP_DE4; ten-eleven translocation-1; TET1 splice variant VP_DE456; CXXC-type zinc finger protein 6; ten-eleven translocation 1 gene protein; leukemia-associated protein with a CXXC domain; tet methylcytosine dioxygenase 1; CXXC-type zinc finger protein 6; Leukemia-associated protein with a CXXC domain; Ten-eleven translocation 1 gene protein]

[TET1]

[TET1; TET1; LCX; CXXC6; bA119F7.1; CXXC6; KIAA1676; LCX]

TET1_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Assay Type: Sandwich (Quantitative). Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of TET1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

156139122

NP_085128.2

NM_030625.2

Q8NFU7

235,309 Da

Epigenetic Regulation Of Gene Expression Pathway (980449); Gene Expression Pathway (105937); TET1,2,3 And TDG Demethylate DNA Pathway (980451)

TET1: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC). Might initiate a process leading to cytosine demethylation through deamination into 5- hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and polycomb-repressed genes. By controlling the levels of 5mC and 5hmC at gene promoters, it may regulate the gene expression silencing induced by cytosine methylation. May have a dual function by also repressing the expression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification. A chromosomal aberration involving TET1 may be a cause of acute leukemias. Translocation t(10;11)(q22;q23) with MLL. This is a rare chromosomal translocation 5 MLL-TET1 3 . Belongs to the TET family. Protein type: DNA-binding; Oxidoreductase; EC 1.14.11.n2. Chromosomal Location of Human Ortholog: 10q21. Cellular Component: nucleus. Molecular Function: structure-specific DNA binding; zinc ion binding; iron ion binding. Biological Process: protein amino acid O-linked glycosylation; inner cell mass cell differentiation; transcription, DNA-dependent; stem cell maintenance; gene expression; positive regulation of transcription from RNA polymerase II promoter; chromatin modification; regulation of gene expression, epigenetic

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095