ELISA/assay

Human Ragulator complex protein LAMTOR1, C11orf59 ELISA Kit

MBS9335196

48-Strip-Wells

435 USD

ELISA Kit

Human Ragulator complex protein LAMTOR1, C11orf59 ELISA Kit

chromosome 11 open reading frame 59

Human Ragulator complex protein LAMTOR1 (C11orf59) ELISA kit; FLJ20625; RhoA activator C11orf59; p27Kip1-releasing factor from RhoA; chromosome 11 open reading frame 59

ragulator complex protein LAMTOR1; Ragulator complex protein LAMTOR1; ragulator complex protein LAMTOR1; RhoA activator C11orf59; lipid raft adaptor protein p18; ragulator complex protein PDRO; p27Kip1-releasing factor from RhoA; p27kip1 releasing factor from RhoA; protein associated with DRMs and endosomes; late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; late endosomal/lysosomal adaptor, MAPK and MTOR activator 1; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; Lipid raft adaptor protein p18; Protein associated with DRMs and endosomes; p27Kip1-releasing factor from RhoA; p27RF-Rho

C11orf59

LAMTOR1; LAMTOR1; p18; PDRO; C11orf59; p27RF-Rho; Ragulator1; C11orf59; PDRO; PP7157; p27RF-Rho

LTOR1_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Serum, Plasma and Tissue Homogenate. Assay Type: Sandwich. Detection Range: 31.2 pg/ml - 1000 pg/ml. Sensitivity: 5.0 pg/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of C11ORF59 (hereafter termed this analyte) in undiluted original Human serum, plasma and tissue homogenate samples.

8923579

NP_060377.1

NM_017907.2

Q6IAA8

17,745 Da

LAMTOR1: Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids. Directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation. Part of the Ragulator complex composed of LAMTOR1, LAMTOR2 and LAMTOR3. Interacts with LAMTOR2 and LAMTOR3; the interaction is direct. The Ragulator complex interacts with both the mTORC1 complex and heterodimers of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD. Interacts with RRAGB and RRAGD; the interaction is direct indicating that it probably constitutes the main RAG-interacting subunit of the Ragulator complex. Interacts with MMP14. Interacts with CDKN1B; prevents the interaction of CDKN1B with RHOA leaving RHOA in a form accessible to activation by ARHGEF2. Protein type: Adaptor/scaffold. Chromosomal Location of Human Ortholog: 11q13.4. Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; lysosome; late endosome membrane; lysosomal membrane; plasma membrane; lipid raft. Molecular Function: protein binding; guanyl-nucleotide exchange factor activity; protein complex scaffold. Biological Process: cholesterol homeostasis; endosome organization and biogenesis; lysosome localization; positive regulation of MAPKKK cascade; lysosome organization and biogenesis; regulation of receptor recycling; cell growth; positive regulation of TOR signaling pathway; endosome localization; positive regulation of GTPase activity

48-Strip-Wells

435 USD

96-Strip-Wells

600