ELISA/assay

Human SOSS complex subunit B2, OBFC2A ELISA Kit

MBS9335034

48-Strip-Wells

470 USD

ELISA Kit

Human SOSS complex subunit B2, OBFC2A ELISA Kit

[oligonucleotide/oligosaccharide-binding fold containing 2A]

[Human SOSS complex subunit B2 (OBFC2A) ELISA kit; DKFZp667M1322; FLJ13624; FLJ22833; MGC111163; SSB2; ; oligonucleotide/oligosaccharide-binding fold containing 2A]

[SOSS complex subunit B2 isoform 1; SOSS complex subunit B2; SOSS complex subunit B2; sensor of ssDNA subunit B2; nucleic acid-binding protein 1; single-stranded DNA-binding protein 2; sensor of single-strand DNA complex subunit B2; oligonucleotide/oligosaccharide-binding fold containing 2A; oligonucleotide/oligosaccharide-binding fold-containing protein 2A; nucleic acid binding protein 1; Nucleic acid-binding protein 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; SOSS-B2; Single-stranded DNA-binding protein 2; hSSB2]

[OBFC2A]

[NABP1; NABP1; SSB2; OBFC2A; SOSS-B2; OBFC2A; SSB2; SOSS-B2; hSSB2]

SOSB2_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: 1.0 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of OBFC2A (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

72534722

NP_001026886.1

NM_001031716.2

Q96AH0

22,423 Da

Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]

OBFC2A: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Belongs to the SOSS-B family. SOSS-B2 subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding; DNA repair, damage; Cell cycle regulation. Chromosomal Location of Human Ortholog: 2q32.3. Cellular Component: nucleoplasm; cytoplasm; nucleus. Molecular Function: RNA binding; single-stranded DNA binding. Biological Process: mitotic cell cycle checkpoint; response to ionizing radiation; DNA repair; response to DNA damage stimulus; double-strand break repair via homologous recombination

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095