Human Na (+) /H (+) exchange regulatory cofactor NHE-RF1, SLC9A3R1 ELISA Kit | MyBioSource MBS9334205 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Na (+) /H (+) exchange regulatory cofactor NHE-RF1, SLC9A3R1 ELISA Kit

catalog :

MBS9334205

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9334205

products type :

ELISA Kit

products full name :

Human Na (+) /H (+) exchange regulatory cofactor NHE-RF1, SLC9A3R1 ELISA Kit

products short name :

[solute carrier family 9 (sodium/hydrogen exchanger) , member 3 regulator 1]

products name syn :

[Human Na (+) /H (+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) ELISA kit; EBP50; NHERF; NHERF1; NPHLOP2; Na+/H+ exchange regulatory co-factor; ezrin-radixin-moesin binding phosphoprotein-50; sodium/hydrogen exchanger regulatory factor 1; solute carrier family 9 (sodium/hydro; solute carrier family 9 (sodium/hydrogen exchanger); member 3 regulator 1]

other names :

[Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Na+/H+ exchange regulatory co-factor; regulatory cofactor of Na(+)/H(+) exchanger; ezrin-radixin-moesin binding phosphoprotein-50; ezrin-radixin-moesin-binding phosphoprotein 50; solute carrier family 9 isoform A3 regulatory factor 1; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1; Ezrin-radixin-moesin-binding phosphoprotein 50; EBP50; Regulatory cofactor of Na(+)/H(+) exchanger; Sodium-hydrogen exchanger regulatory factor 1; Solute carrier family 9 isoform A3 regulatory factor 1]

products gene name :

[SLC9A3R1]

other gene names :

[SLC9A3R1; SLC9A3R1; EBP50; NHERF; NHERF1; NHERF-1; NPHLOP2; NHERF; NHERF1; NHERF-1; EBP50]

uniprot entry name :

NHRF1_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Assay Type: Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: The sensitivity of this kit is 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of SLC9A3R1 (hereafter termed this analyte) in undiluted original Human body fluids, tissue homogenates, secretions and feces samples.

ncbi gi num :

4759140

ncbi acc num :

NP_004243.1

ncbi gb acc num :

NM_004252.4

uniprot acc num :

O14745

ncbi mol weight :

38,868 Da

ncbi pathways :

PDGFR-beta Signaling Pathway (138071); Thromboxane A2 Receptor Signaling Pathway (138060)

ncbi summary :

This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.[provided by RefSeq, Sep 2009]

uniprot summary :

NHERF: a scaffold protein that connects plasma membrane proteins with members of the Ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized beta-2-adrenergic receptor Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 17q25.1. Cellular Component: centrosome; microvillus; intracellular membrane-bound organelle; brush border membrane; endomembrane system; actin cytoskeleton; lipid raft; ruffle; membrane; microvillus membrane; apical plasma membrane; cytoplasm; plasma membrane; nucleus; vesicle; filopodium. Molecular Function: protein binding; chloride channel regulator activity; protein self-association; beta-2 adrenergic receptor binding; beta-catenin binding; protein complex binding; dopamine receptor binding; protein complex scaffold; PDZ domain binding; phosphatase binding; receptor binding. Biological Process: bile acid secretion; negative regulation of protein kinase B signaling cascade; Wnt receptor signaling pathway; renal sodium ion transport; microvillus biogenesis; negative regulation of cell proliferation; cellular phosphate ion homeostasis; regulation of sodium:hydrogen antiporter activity; protein complex assembly; dopamine receptor, phospholipase C activating pathway; regulation of protein kinase activity; negative regulation of sodium:hydrogen antiporter activity; actin cytoskeleton organization and biogenesis; negative regulation of cell migration; dopamine receptor, adenylate cyclase activating pathway; negative regulation of phosphoinositide 3-kinase cascade. Disease: Nephrolithiasis/osteoporosis, Hypophosphatemic, 2

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage