ELISA/assay

Pig Troponin C, slow skeletal and cardiac muscles, TNNC1 ELISA Kit

MBS9334132

48-Strip-Wells

470 USD

ELISA Kit

Pig Troponin C, slow skeletal and cardiac muscles, TNNC1 ELISA Kit

[troponin C type 1 (slow)]

[Pig Troponin C; slow skeletal and cardiac muscles (TNNC1) ELISA kit; CMD1Z; TNC; TNNC; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; troponin C; slow; troponin C1; slow; troponin C type 1 (slow)]

[troponin C, slow skeletal and cardiac muscles; Troponin C, slow skeletal and cardiac muscles; troponin C, slow skeletal and cardiac muscles; TN-C]

[TNNC1]

[TNNC1; TNNC1; TNNC; TNNC; TN-C]

TNNC1_PIG

Pig

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Undiluted original Porcine body fluids, tissue homogenates, secretions or feces samples. Assay Type: Sandwich. Detection Range: 62.5 pg/ml - 2000 pg/ml. Sensitivity: 10 pg/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of TNNC1 (hereafter termed "analyte") in undiluted original Porcine body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

194332498

NP_001123715.1

NM_001130243.1

P63317

18,417 Da

Adrenergic Signaling In Cardiomyocytes Pathway (908279); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Calcium Signaling Pathway (84462); Calcium Signaling Pathway (459); Cardiac Muscle Contraction Pathway (93350); Cardiac Muscle Contraction Pathway (93992); Dilated Cardiomyopathy Pathway (121477); Dilated Cardiomyopathy Pathway (121285); Hypertrophic Cardiomyopathy (HCM) Pathway (114046); Hypertrophic Cardiomyopathy (HCM) Pathway (106591)

TNNC1: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13). A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Belongs to the troponin C family. Protein type: Motility/polarity/chemotaxis; Calcium-binding. Chromosomal Location of Human Ortholog: 3p21.1. Cellular Component: nucleoplasm; troponin complex; mitochondrion; cytosol; actin cytoskeleton. Molecular Function: troponin T binding; actin filament binding; protein binding; protein homodimerization activity; troponin I binding; calcium ion binding; calcium-dependent protein binding. Biological Process: regulation of ATPase activity; response to metal ion; regulation of muscle contraction; diaphragm contraction; ventricular cardiac muscle morphogenesis; regulation of muscle filament sliding speed; muscle filament sliding; cardiac muscle contraction. Disease: Cardiomyopathy, Dilated, 1z; Cardiomyopathy, Familial Hypertrophic, 13

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095