Human Dynein intermediate chain 1, axonemal, DNAI1 ELISA Kit | MyBioSource MBS9334054 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Dynein intermediate chain 1, axonemal, DNAI1 ELISA Kit

catalog :

MBS9334054

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9334054

products type :

ELISA Kit

products full name :

Human Dynein intermediate chain 1, axonemal, DNAI1 ELISA Kit

products short name :

[dynein, axonemal, intermediate chain 1]

products name syn :

[Human Dynein intermediate chain 1; axonemal (DNAI1) ELISA kit; RP11-296L22.2; CILD1; ICS; ICS1; MGC26204; PCD; dynein intermediate chain DNAI1; dynein; axonemal; intermediate polypeptide 1; immotile cilia syndrome 1; dynein; axonemal; intermediate chain 1]

other names :

[dynein intermediate chain 1, axonemal isoform 2; Dynein intermediate chain 1, axonemal; dynein intermediate chain 1, axonemal; immotile cilia syndrome 1; dynein, axonemal, intermediate polypeptide 1; dynein, axonemal, intermediate chain 1; Axonemal dynein intermediate chain 1]

products gene name :

[DNAI1]

other gene names :

[DNAI1; DNAI1; PCD; DIC1; ICS1; CILD1]

uniprot entry name :

DNAI1_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: 1.0 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of DNAI1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

526479830

ncbi acc num :

NP_001268357.1

ncbi gb acc num :

NM_001281428.1

uniprot acc num :

Q9UI46

ncbi mol weight :

79,283 Da

ncbi pathways :

Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512)

ncbi summary :

This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

uniprot summary :

DNAI1: Part of the dynein complex of respiratory cilia. Defects in DNAI1 are the cause of primary ciliary dyskinesia type 1 (CILD1). CILD1 is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Defects in DNAI1 are the cause of Kartagener syndrome (KTGS). KTGS is an autosomal recessive disorder characterized by the association of primary ciliary dyskinesia with situs inversus. Clinical features include recurrent respiratory infections, bronchiectasis, infertility, and lateral transposition of the viscera of the thorax and abdomen. The situs inversus is most often total, although it can be partial in some cases (isolated dextrocardia or isolated transposition of abdominal viscera). Belongs to the dynein intermediate chain family. Protein type: Cytoskeletal; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 9p13.3. Cellular Component: dynein complex; microtubule; cytoskeleton; cytoplasm; cilium. Molecular Function: protein binding; motor activity. Biological Process: cell projection organization and biogenesis; metabolic process. Disease: Ciliary Dyskinesia, Primary, 1

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage