catalog number :
MBS9333663
products type :
ELISA Kit
products full name :
Human RING finger protein 11, RNF11 ELISA Kit
products short name :
[ring finger protein 11]
products name syn :
[Human RING finger protein 11 (RNF11) ELISA kit; CGI-123; MGC51169; SID1669; ; ring finger protein 11]
other names :
[RING finger protein 11; RING finger protein 11; RING finger protein 11; ring finger protein 11]
products gene name :
[RNF11]
other gene names :
[RNF11; RNF11; CGI-123; SID1669; CGI-123]
uniprot entry name :
RNF11_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Assay Type: Sandwich (Quantitative). Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: 1.0 ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of RNF11 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_055187.1
ncbi gb acc num :
NM_014372.4
ncbi mol weight :
17,444 Da
ncbi summary :
The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008]
uniprot summary :
RNF11: Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates Lys-63 polyubiquitin chains on RIPK1 and catalyzes the formation of Lys-48 -polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome. Protein type: Ubiquitin ligase; EC 6.3.2.-; Ubiquitin conjugating system; Ligase. Chromosomal Location of Human Ortholog: 1p32. Cellular Component: recycling endosome; early endosome; nucleus; ubiquitin ligase complex. Molecular Function: protein binding; DNA binding; zinc ion binding; ubiquitin-protein ligase activity. Biological Process: protein autoubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
size4 :
10x96-Strip-Wells