catalog number :
MBS9332938
products type :
ELISA Kit
products full name :
Rat Testosterone 17-beta-dehydrogenase 3, HSD17B3 ELISA Kit
products short name :
[hydroxysteroid (17-beta) dehydrogenase 3]
products name syn :
[Rat Testosterone 17-beta-dehydrogenase 3 (HSD17B3) ELISA kit; EDH17B3; SDR12C2; 17-beta-HSD3; estradiol 17 beta-dehydrogenase 3; short chain dehydrogenase/reductase family 12C; member 2; testicular 17-beta-hydroxysteroid dehydrogenase; hydroxysteroid (17-beta) dehydrogenase 3]
other names :
[testosterone 17-beta-dehydrogenase 3; Testosterone 17-beta-dehydrogenase 3; testosterone 17-beta-dehydrogenase 3; 17beta-HSD; 17-beta-HSD 3; estradiol 17 beta-dehydrogenase 3; 17-beta-hydroxysteroid dehydrogenase type 3; testicular 17-beta-hydroxysteroid dehydrogenase; hydroxysteroid (17-beta) dehydrogenase 3; 17-beta-hydroxysteroid dehydrogenase type 3; 17-beta-HSD 3; Testicular 17-beta-hydroxysteroid dehydrogenase]
products gene name :
[HSD17B3]
other gene names :
[Hsd17b3; Hsd17b3; Edh17b3; 17-beta-HSD 3]
uniprot entry name :
DHB3_RAT
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Assay Type: Quantitative Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of HSD17B3 (hereafter termed "analyte") in undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_446459.1
ncbi gb acc num :
NM_054007.1
ncbi mol weight :
34,223 Da
ncbi pathways :
Androgen Biosynthesis Pathway (574000); Metabolism Pathway (573935); Metabolism Of Lipids And Lipoproteins Pathway (573950); Metabolism Of Steroid Hormones And Vitamins A And D Pathway (573996); Steroid Biosynthesis Pathway (198481); Steroid Hormone Biosynthesis Pathway (83333); Steroid Hormone Biosynthesis Pathway (301)
ncbi summary :
catalyzes the final step of testosterone biosynthesis in the testis [RGD, Feb 2006]
uniprot summary :
HSD17B3: Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH. Defects in HSD17B3 are the cause of male pseudohermaphrodism with gynecomastia (MPH). These individuals have unambiguous female external genitalia at birth, but fail to menstruate at the time of expected puberty and instead virilize as evidenced by growth of the phallus. Breast development may or may not take place. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. Protein type: Oxidoreductase; Lipid Metabolism - androgen and estrogen; EC 1.1.1.64. Cellular Component: intracellular membrane-bound organelle. Molecular Function: estradiol 17-beta-dehydrogenase activity; testosterone 17-beta-dehydrogenase (NADP+) activity; oxidoreductase activity; 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity. Biological Process: response to nutrient levels; response to metal ion; insecticide metabolic process; response to arsenic; hippocampus development; response to herbicide; response to insecticide; response to L-ascorbic acid; response to organic cyclic substance; cellular response to hormone stimulus; organic acid metabolic process; response to vitamin E; response to cadmium ion; Leydig cell differentiation; response to ethanol; biphenyl metabolic process; response to estrogen stimulus; response to steroid hormone stimulus; response to lead ion; response to activity; steroid biosynthetic process; phenol metabolic process; response to corticosterone stimulus
size4 :
10x96-Strip-Wells