ELISA/assay

Human Protein MB21D1, C6orf150 ELISA Kit

MBS9332833

48-Strip-Wells

470 USD

ELISA Kit

Human Protein MB21D1, C6orf150 ELISA Kit

[chromosome 6 open reading frame 150]

[Human Protein MB21D1 (C6orf150) ELISA kit; MGC131892; MGC142166; MGC142168; hypothetical protein LOC115004; chromosome 6 open reading frame 150]

[cyclic GMP-AMP synthase; Cyclic GMP-AMP synthase; cyclic GMP-AMP synthase; cGAMP synthase; protein MB21D1; mab-21 domain-containing protein 1; Mab-21 domain containing 1; Mab-21 domain-containing protein 1]

[C6orf150]

[MB21D1; MB21D1; cGAS; h-cGAS; C6orf150; C6orf150; cGAMP synthase; cGAS; h-cGAS]

CGAS_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Human Body Fluids And Tissue Homogenates. Assay Type: Quantitative Sandwich. Detection Range: 31.2pg/ml-1000pg/ml. Sensitivity: 5.0pg/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determine the level of C6ORF105 (hereafter termed "analyte") in undiluted original Human body fluids and tissue homogenates. This kit is NOT suitable for assaying non-biological sources of substances.

115511030

NP_612450.2

NM_138441.2

Q8N884

58,814 Da

Cytosolic DNA-sensing Pathway (125137); Cytosolic DNA-sensing Pathway (124833); Cytosolic Sensors Of Pathogen-associated DNA Pathway (576255); Immune System Pathway (106386); Innate Immune System Pathway (106387); STING Mediated Induction Of Host Immune Responses Pathway (685548)

MB21D1: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2 ,5 phosphodiester linkage at the GpA step and the formation of a 3 ,5 phosphodiester linkage at the ApG step, producing c[G(2 ,5 )pA(3 ,5 )p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. Protein type: Enzyme, cellular metabolism; EC 2.7.7.86. Chromosomal Location of Human Ortholog: 6q13. Cellular Component: cytosol. Molecular Function: DNA binding; GTP binding; metal ion binding; ATP binding. Biological Process: cyclic nucleotide biosynthetic process; positive regulation of interferon type I production; innate immune response; positive regulation of defense response to virus by host; defense response to virus; activation of innate immune response

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095