ELISA/assay

Human Protein unc-93 homolog B1, UNC93B1 ELISA Kit

MBS9332364

48-Strip-Wells

435 USD

ELISA Kit

Human Protein unc-93 homolog B1, UNC93B1 ELISA Kit

unc-93 homolog B1 (C. elegans)

Human Protein unc-93 homolog B1 (UNC93B1) ELISA kit; MGC126617; UNC93; UNC93B; unc-93 homolog B1; unc-93 related protein; unc93 homolog B; unc93 homolog B1; unc-93 homolog B1 (C. elegans)

protein unc-93 homolog B1; Protein unc-93 homolog B1; protein unc-93 homolog B1; unc93 homolog B1; unc-93 related protein; unc-93 homolog B1 (C. elegans)

UNC93B1

UNC93B1; UNC93B1; IIAE1; UNC93; UNC93B; Unc-93B1; UNC93; UNC93B; Unc-93B1; hUNC93B1

UN93B_HUMAN

Human

Store all reagents at 2-8 degree C

45580709

NP_112192.2

NM_030930.3

Q9H1C4

66,631 Da

Immune System Pathway (106386); Innate Immune System Pathway (106387); Toll Receptor Cascades Pathway (106388); Trafficking And Processing Of Endosomal TLR Pathway (576253)

This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. [provided by RefSeq, Feb 2014]

UNC93B1: Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B- cells removal. Defects in UNC93B1 are associated with herpes simplex encephalitis type 1 (HSE1). HSE is a rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. Mutations in UNC93B1 resulting in autosomal recessive UNC93B1 deficieny predispose otherwise healthy individuals to isolated herpes simplex encephalitis due to impaired IFNs production. UNC93B1 deficieny, however, does not compromise immunity to most pathogens, unlike most known primary immunodeficiencies. Belongs to the unc-93 family. Protein type: Cell surface; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 11q13. Cellular Component: Golgi membrane; endoplasmic reticulum membrane; endoplasmic reticulum; lysosome; integral to membrane; endosome. Biological Process: intracellular protein transport; toll-like receptor signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class II; innate immune response; toll-like receptor 3 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor 7 signaling pathway; defense response to virus. Disease: Herpes Simplex Encephalitis, Susceptibility To, 1

48-Strip-Wells

435 USD

96-Strip-Wells

600