ELISA/assay

Human Class E basic helix-loop-helix protein 41, BHLHE41 ELISA Kit

MBS9332323

96 Strip Wells

600 USD

ELISA Kit

Human Class E basic helix-loop-helix protein 41, BHLHE41 ELISA Kit

basic helix-loop-helix family, member e41

Human Class E basic helix-loop-helix protein 41 (BHLHE41) ELISA kit; BHLHB3; DEC2; SHARP-1; SHARP1; bHLH protein DEC2; basic helix-loop-helix domain containing; class B; 3; differentially expressed in chondrocytes 2; basic helix-loop-helix family; member e41

class E basic helix-loop-helix protein 41; Class E basic helix-loop-helix protein 41; class E basic helix-loop-helix protein 41; enhancer-of-split and hairy-related protein 1; differentially expressed in chondrocytes protein 2; basic helix-loop-helix domain containing, class B, 3; basic helix-loop-helix family, member e41; Class B basic helix-loop-helix protein 3; bHLHb3; Differentially expressed in chondrocytes protein 2; hDEC2; Enhancer-of-split and hairy-related protein 1; SHARP-1

BHLHE41

BHLHE41; BHLHE41; DEC2; hDEC2; BHLHB3; SHARP1; BHLHB3; DEC2; SHARP1; bHLHe41; bHLHb3; hDEC2; SHARP-1

BHE41_HUMAN

Human

13540521

NP_110389.1

NM_030762.2

Q9C0J9

50,498 Da

BMAL1:CLOCK/NPAS2 Activates Circadian Expression Pathway 477138!!Circadian Clock Pathway 187173!!Circadian Rhythm - Mammal Pathway 83084!!Circadian Rhythm - Mammal Pathway 495!!HIF-1-alpha Transcription Factor Network Pathway 138045

This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype. [provided by RefSeq, Feb 2014]

Function: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.6 PublicationsManual assertion based on experiment in:Ref.4

96 Strip Wells

600 USD