ELISA/assay

Human TNFAIP3-interacting protein 2, TNIP2 ELISA Kit

MBS9332301

48-Strip-Wells

470 USD

ELISA Kit

Human TNFAIP3-interacting protein 2, TNIP2 ELISA Kit

[TNFAIP3 interacting protein 2]

[Human TNFAIP3-interacting protein 2 (TNIP2) ELISA kit; RP3-474M20.1; ABIN2; DKFZp434J1313; FLIP1; KLIP; MGC4289; A20-binding inhibitor of NF-kappaB activation 2; A20-binding inhibitor of NF-kappaB activation-2; fetal liver LKB1-interacting protein; TNFAIP3 interacting protein 2]

[TNFAIP3-interacting protein 2 isoform 2; TNFAIP3-interacting protein 2; TNFAIP3-interacting protein 2; fetal liver LKB1-interacting protein; A20-binding inhibitor of NF-kappaB activation-2; TNFAIP3 interacting protein 2; A20-binding inhibitor of NF-kappa-B activation 2; ABIN-2; Fetal liver LKB1-interacting protein]

[TNIP2]

[TNIP2; TNIP2; KLIP; ABIN2; FLIP1; ABIN2; FLIP1; ABIN-2]

TNIP2_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 31.2 pg/ml - 1000 pg/ml. Sensitivity: 5.0 pg/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of TNIP2 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

239787094

NP_001154999.1

NM_001161527.1

Q8NFZ5

48,700 Da

Cytokine Signaling In Immune System Pathway (366171); Immune System Pathway (106386); Interleukin-1 Signaling Pathway (160141); Signaling By Interleukins Pathway (160140); TNF-alpha/NF-kB Signaling Pathway (198884)

This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]

TNIP2: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. 2 isoforms of the human protein are produced by alternative splicing. Chromosomal Location of Human Ortholog: 4p16.3. Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol. Molecular Function: protein binding; polyubiquitin binding; protein kinase binding. Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; protein stabilization; apoptosis; positive regulation of B cell activation; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 3 signaling pathway; toll-like receptor 9 signaling pathway; inflammatory response; toll-like receptor 2 signaling pathway; positive regulation of macrophage activation

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095