Rat RE1-silencing transcription factor, REST ELISA Kit | MyBioSource MBS9332070 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Rat RE1-silencing transcription factor, REST ELISA Kit

catalog :

MBS9332070

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9332070

products type :

ELISA Kit

products full name :

Rat RE1-silencing transcription factor, REST ELISA Kit

products short name :

[RE1-silencing transcription factor]

products name syn :

[Rat RE1-silencing transcription factor (REST) ELISA kit; NRSF; XBR; neuron restrictive silencer factor; repressor binding to the X2 box; RE1-silencing transcription factor]

other names :

[RE1-silencing transcription factor; RE1-silencing transcription factor; RE1-silencing transcription factor; neural-restrictive silencer factor; zinc finger transcription factor REST protein; RE1-silencing transcription factor; Neural-restrictive silencer factor]

products gene name :

[REST]

other gene names :

[Rest; Rest; Nrsf]

uniprot entry name :

REST_RAT

reactivity :

Rat

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Rat Body Fluids And Tissue Homogenates. Assay Type: Quantitative Sandwich. Detection Range: 6.25pg/ml-200pg/ml. Sensitivity: 1.0pg/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determine the level of RENIN (hereafter termed "analyte") in undiluted original Rat body fluids and tissue homogenates. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

13929116

ncbi acc num :

NP_113976.1

ncbi gb acc num :

NM_031788.1

uniprot acc num :

O54963

ncbi mol weight :

117,126 Da

ncbi pathways :

Huntington's Disease Pathway (83492); Huntington's Disease Pathway (512); SIDS Susceptibility Pathways (219790)

ncbi summary :

represses transcription of the AMPA receptor (AMPAR) subunit GluR2 and other neural genes [RGD, Feb 2006]

uniprot summary :

REST: a transcriptional repressor that binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells during embryonic development. Induced during ageing in human cortical and hippocampal neurons, where it represses genes that promote cell death and induces the expression of stress response genes. Protects neurons from amyloid beta- and oxidative stress-induced toxicity. The deletion of REST in the mouse brain induces age-related neurodegeneration. Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. REST activates DYRK1A transcription via a neuron-restricted silencer element in the DYRK1A promoter. Four isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor; DNA-binding; C2H2-type zinc finger protein; Cell development/differentiation. Cellular Component: protein complex; transcriptional repressor complex; chromatin; cytosol; nucleus. Molecular Function: protein binding; nucleic acid binding; DNA binding; metal ion binding; outward rectifier potassium channel activity; protein complex binding; chromatin binding; transcription factor activity; transcription factor binding. Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; negative regulation of neuron differentiation; negative regulation of calcium ion-dependent exocytosis; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of aldosterone biosynthetic process; positive regulation of caspase activity; positive regulation of transcription from RNA polymerase II promoter; hemopoietic progenitor cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of neurogenesis; negative regulation of insulin secretion

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage