catalog number :
MBS9332004
products type :
ELISA Kit
products full name :
Human Proto-oncogene c-Rel, REL ELISA Kit
products short name :
[v-rel reticuloendotheliosis viral oncogene homolog (avian)]
products name syn :
[Human Proto-oncogene c-Rel (REL) ELISA kit; C-Rel; C-Rel proto-oncogene protein; oncogene REL; avian reticuloendotheliosis; v-rel avian reticuloendotheliosis viral oncogene homolog; v-rel reticuloendotheliosis viral oncogene homolog; v-rel reticuloendotheliosis viral oncogene homolog (avian)]
other names :
[proto-oncogene c-Rel isoform 1; Proto-oncogene c-Rel; proto-oncogene c-Rel; oncogene REL, avian reticuloendotheliosis; v-rel avian reticuloendotheliosis viral oncogene homolog]
products gene name :
[REL]
other gene names :
[REL; REL; C-Rel]
uniprot entry name :
REL_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Assay Type: Quantitative Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: 1.0 ng/ml
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of REL (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_002899.1
ncbi gb acc num :
NM_002908.3
ncbi mol weight :
68,520 Da
ncbi pathways :
Activation Of NF-kappaB In B Cells Pathway (576251); Adaptive Immune System Pathway (366160); Atypical NF-kappaB Pathway (137946); B Cell Receptor Signaling Pathway (198909); Downstream Signaling Events Of B Cell Receptor (BCR) Pathway (576250); Immune System Pathway (106386); Regulation Of Androgen Receptor Activity Pathway (138027); Signaling By The B Cell Receptor (BCR) Pathway (576248); TNF-alpha/NF-kB Signaling Pathway (198884); Transcriptional Misregulation In Cancer Pathway (523016)
ncbi summary :
This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
uniprot summary :
REL: a proto-oncogenic transcription factor of the nuclear factor-kappaB (NFkB) group. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. May play a role in differentiation and lymphopoiesis. Protein type: Oncoprotein; Transcription factor. Chromosomal Location of Human Ortholog: 2p13-p12. Cellular Component: nucleoplasm; transcription factor complex; cytosol. Molecular Function: protein binding; chromatin binding; transcription factor activity. Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 biosynthetic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; response to cytokine stimulus; innate immune response; cytokine production; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; inflammatory response
size4 :
10x96-Strip-Wells