Human Zinc finger protein 423, ZNF423 ELISA Kit | MyBioSource MBS9331861 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Zinc finger protein 423, ZNF423 ELISA Kit

catalog :

MBS9331861

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS9331861

products type :

ELISA Kit

products full name :

Human Zinc finger protein 423, ZNF423 ELISA Kit

products short name :

[zinc finger protein 423]

products name syn :

[Human Zinc finger protein 423 (ZNF423) ELISA kit; Ebfaz; KIAA0760; MGC138520; MGC138522; OAZ; Roaz; ZFP423; Zfp104; OLF-1/EBF associated zinc finger; Smad- and Olf-interacting zinc finger protein; early B-cell factor associated zinc finger protein; zinc finger protein 423]

other names :

[zinc finger protein 423 isoform 2; Zinc finger protein 423; zinc finger protein 423; hOAZ; OLF-1/EBF associated zinc finger; olf1/EBF-associated zinc finger protein; Smad- and Olf-interacting zinc finger protein; early B-cell factor associated zinc finger protein; zinc finger protein 423; Olf1/EBF-associated zinc finger protein; hOAZ; Smad- and Olf-interacting zinc finger protein]

products gene name :

[ZNF423]

other gene names :

[ZNF423; ZNF423; OAZ; Roaz; Ebfaz; JBTS19; NPHP14; ZFP423; Zfp104; KIAA0760; NPHP14; OAZ; hOAZ]

uniprot entry name :

ZN423_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between Human ZNF423 and analogues was observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Serum, Plasma, Tissue Homogenate, Feces and Urine. Assay Type: Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: 1.0 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Intended Uses: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! It is intended to be determinated ZNF423 concentrations in Human serum, plasma and other body fluids. Using Purified Human ZNF423 antibody to coat Microelisa Stripplate wells to make solid-phase antibody, then add ZNF423 and ZNF423 antibody which has been labeled with HRP to wells, then the reactants become antibody-antigen-antibody-enzyme complex, after washing completely, add TMB substrate solution, TMB substrate becomes blue color under HRP enzyme-catalyzed, reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm. The concentration of ZNF423 in the samples is then determined by comparing the O.D. of the samples to the standard curve.

ncbi gi num :

410110906

ncbi acc num :

NP_001258549.1

ncbi gb acc num :

NM_001271620.1

uniprot acc num :

Q2M1K9

ncbi mol weight :

144,605 Da

ncbi pathways :

TGF Beta Signaling Pathway (198810)

ncbi summary :

The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development. Mutations in this gene are associated with nephronophthisis-14 and Joubert syndrome-19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2012]

uniprot summary :

ZNF423: Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. Defects in ZNF423 can be a cause of nephronophthisis-related ciliopathies (NPHP-RC), a group of recessive diseases that affect kidney, retina and brain. ZNF423 mutations have been found in patients with nephronophthisis, cerebellar vermis hypoplasia and situs inversus, and Joubert syndrome. Belongs to the krueppel C2H2-type zinc-finger protein family. Protein type: C2H2-type zinc finger protein; DNA-binding. Chromosomal Location of Human Ortholog: 16q12. Cellular Component: nucleus. Molecular Function: protein binding; DNA binding; metal ion binding. Biological Process: nervous system development; Notch signaling pathway; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; cell differentiation; positive regulation of BMP signaling pathway. Disease: Nephronophthisis 14

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095