Human RAS guanyl-releasing protein 1, RASGRP1 ELISA Kit | MyBioSource MBS9331756 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human RAS guanyl-releasing protein 1, RASGRP1 ELISA Kit

catalog :

MBS9331756

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9331756

products type :

ELISA Kit

products full name :

Human RAS guanyl-releasing protein 1, RASGRP1 ELISA Kit

products short name :

[RAS guanyl releasing protein 1 (calcium and DAG-regulated)]

products name syn :

[Human RAS guanyl-releasing protein 1 (RASGRP1) ELISA kit; CALDAG-GEFI; CALDAG-GEFII; MGC129998; MGC129999; RASGRP; V; hRasGRP1; RAS guanyl nucleotide-releasing protein 1; RAS guanyl releasing protein 1; calcium and DAG-regulated guanine nucleotide exchange f; RAS guanyl releasing protein 1 (calcium and DAG-regulated)]

other names :

[RAS guanyl-releasing protein 1 isoform b; RAS guanyl-releasing protein 1; RAS guanyl-releasing protein 1; ras activator RasGRP; RAS guanyl nucleotide-releasing protein 1; calcium and DAG-regulated guanine nucleotide exchange factor II; guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A; RAS guanyl releasing protein 1 (calcium and DAG-regulated); Calcium and DAG-regulated guanine nucleotide exchange factor II; CalDAG-GEFII; Ras guanyl-releasing protein]

products gene name :

[RASGRP1]

other gene names :

[RASGRP1; RASGRP1; V; RASGRP; hRasGRP1; CALDAG-GEFI; CALDAG-GEFII; RASGRP; CalDAG-GEFII]

uniprot entry name :

GRP1_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Serum, Plasma and Tissue Homogenate. Assay Type: Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: 1.0 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of RASGRP1 (hereafter termed this analyte) in undiluted original Human serum, plasma and tissue homogenate samples.

ncbi gi num :

190684646

ncbi acc num :

NP_001122074.1

ncbi gb acc num :

NM_001128602.1

uniprot acc num :

O95267

ncbi mol weight :

90,402 Da

ncbi pathways :

Activation Of RAS In B Cells Pathway (576252); Adaptive Immune System Pathway (366160); Downstream Signaling Events Of B Cell Receptor (BCR) Pathway (576250); Effects Of PIP2 Hydrolysis Pathway (106044); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); Hemostasis Pathway (106028); Immune System Pathway (106386); Integrin AlphaIIb Beta3 Signaling Pathway (106054); Integrin Cell Surface Interactions Pathway (106110)

ncbi summary :

This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]

uniprot summary :

RASGRP1: Functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Couples T-lymphocytes and B-lymphocytes antigen receptors to the activation of Ras. Hence, regulates T-cells and B-cells development, homeostasis and differentiation. Functions also in FcERI-evoked degranulation and cytokine secretion by mast cells, regulating allergic responses. May also function in other cell types differentiation. Defects in RASGRP1 may contribute to susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Aberrantly spliced isoforms and/or diminished levels of RASGRP1 are found in a cohort of SLE patients raising the possibility that dysregulation of this signaling protein contributes to the development of autoimmunity in a subset of SLE patients. Belongs to the RASGRP family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: GEFs, Ras; GEFs. Chromosomal Location of Human Ortholog: 15q14. Cellular Component: Golgi membrane; endoplasmic reticulum membrane; mast cell granule; membrane; plasma membrane; cytosol. Molecular Function: guanyl-nucleotide exchange factor activity; calcium ion binding; lipid binding. Biological Process: platelet activation; inflammatory response to antigenic stimulus; Ras protein signal transduction; regulation of phosphoinositide 3-kinase cascade; vesicle transport along microtubule; innate immune response; cytokine production; mast cell degranulation; signal transduction; cell differentiation; blood coagulation; secretory granule localization

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage