catalog number :
MBS9331635
products type :
ELISA Kit
products full name :
Mouse Interferon regulatory factor 8, IRF8 ELISA Kit
products short name :
[interferon regulatory factor 8]
products name syn :
[Mouse Interferon regulatory factor 8 (IRF8) ELISA kit; H-ICSBP; ICSBP; ICSBP1; IRF-8; interferon consensus sequence binding protein 1; interferon regulatory factor 8]
other names :
[interferon regulatory factor 8; Interferon regulatory factor 8; interferon regulatory factor 8; interferon consensus sequence-binding protein; interferon consensus sequence binding protein 1; interferon regulatory factor 8; Interferon consensus sequence-binding protein; ICSBP]
products gene name :
[IRF8]
other gene names :
[Irf8; Irf8; Myls; ICSBP; IRF-8; Icsbp1; AI893568; Icsbp; Icsbp1; IRF-8; ICSBP]
uniprot entry name :
IRF8_MOUSE
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Assay Type: Quantitative Sandwich. Detection Range: 31.2 pg/ml - 1000 pg/ml. Sensitivity: 5.0 pg/ml
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of IRF8 (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_032346.1
ncbi gb acc num :
NM_008320.3
ncbi mol weight :
48,237 Da
ncbi pathways :
Pertussis Pathway (218112); Pertussis Pathway (218099); Type II Interferon Signaling (IFNG) Pathway (198408)
ncbi summary :
The protein encoded by this gene is a transcription factor that belongs to the interferon regulatory factor family. Proteins belonging to this family have a DNA binding domain at the amino terminus that contains five well-conserved tryptophan-rich repeats. This domain recognizes DNA sequences similar to the interferon-stimulated response element. The protein encoded by this gene promotes or suppresses lineage-specific genes to regulate the differentation of lymphoid and myeloid lineage cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
uniprot summary :
IRF8: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Interacts (via C-terminus) with TRIM21 (via C-terminus). Interacts with COPS2. By IFNG/IFN-gamma. Predominantly expressed in lymphoid tissues. Belongs to the IRF family. Protein type: Transcription factor; DNA-binding. Cellular Component: nucleoplasm; nucleus. Molecular Function: protein binding; DNA binding; transcription factor activity. Biological Process: positive regulation of interferon-gamma production; response to bacterium; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of interleukin-12 production; positive regulation of transcription, DNA-dependent; defense response to bacterium; immune response; myeloid cell differentiation; defense response to protozoan; phagocytosis
size4 :
10x96-Strip-Wells