product summary
Loading...
company name :
MyBioSource
product type :
ELISA/assay
product name :
Human Merlin, NF2 ELISA Kit
catalog :
MBS9331611
quantity :
48-Strip-Wells
price :
435 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS9331611
products type :
ELISA Kit
products full name :
Human Merlin, NF2 ELISA Kit
products short name :
neurofibromin 2 (merlin)
products name syn :
Human Merlin (NF2) ELISA kit; ACN; BANF; SCH; merlin; moesin-ezrin-radixin like; moesin-ezrin-radizin-like protein; neurofibromin 2; neurofibromin 2 (bilateral acoustic neuroma) ; schwannomerlin; schwannomin; neurofibromin 2 (merlin)
other names :
merlin isoform 1; Merlin; merlin; schwannomin; schwannomerlin; neurofibromin-2; moesin-ezrin-radixin like; moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; neurofibromin 2 (bilateral acoustic neuroma); neurofibromin 2 (merlin); Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomerlin; Schwannomin
products gene name :
NF2
other gene names :
NF2; NF2; ACN; SCH; BANF; SCH
uniprot entry name :
MERL_HUMAN
reactivity :
Human
storage stability :
Store all reagents at 2-8 degree C
ncbi gi num :
4557795
ncbi acc num :
NP_000259.1
ncbi gb acc num :
NM_000268.3
uniprot acc num :
P35240
ncbi mol weight :
69,690 Da
ncbi pathways :
ErbB2/ErbB3 Signaling Events Pathway (137955)
ncbi summary :
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008]
uniprot summary :
Merlin: a moesin-ezrin-radizin-like protein. Interacts with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. Expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations are associated with neurofibromatosis type II. Two predominant isoforms and eight minor isoforms are produced by alternatively spliced transcripts. Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor. Chromosomal Location of Human Ortholog: 22q12.2. Cellular Component: filopodium membrane; cortical actin cytoskeleton; early endosome; adherens junction; extrinsic to membrane; cytoskeleton; membrane; lamellipodium; apical part of cell; perinuclear region of cytoplasm; cytoplasm; plasma membrane; nucleolus; nucleus; cleavage furrow. Molecular Function: protein binding; actin binding. Biological Process: intercellular junction assembly and maintenance; negative regulation of MAPKKK cascade; hippocampus development; regulation of protein stability; negative regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of cell-matrix adhesion; odontogenesis of dentine-containing teeth; negative regulation of cell proliferation; Schwann cell proliferation; mesoderm formation; negative regulation of DNA replication; positive regulation of stress fiber formation; negative regulation of tyrosine phosphorylation of Stat3 protein; ectoderm development; negative regulation of protein kinase activity; negative regulation of cell-cell adhesion; positive regulation of cell differentiation; actin cytoskeleton organization and biogenesis; negative regulation of cell migration; negative regulation of JAK-STAT cascade. Disease: Meningioma, Familial, Susceptibility To; Neurofibromatosis, Type Ii; Schwannomatosis 1
size1 :
48-Strip-Wells
price1 :
435 USD
size2 :
96-Strip-Wells
price2 :
600
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!