Human Long-chain-fatty-acid--CoA ligase 4, ACSL4 ELISA Kit | MyBioSource MBS9331516 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Long-chain-fatty-acid--CoA ligase 4, ACSL4 ELISA Kit

catalog :

MBS9331516

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9331516

products type :

ELISA Kit

products full name :

Human Long-chain-fatty-acid--CoA ligase 4, ACSL4 ELISA Kit

products short name :

[acyl-CoA synthetase long-chain family member 4]

products name syn :

[Human Long-chain-fatty-acid--CoA ligase 4 (ACSL4) ELISA kit; ACS4; FACL4; LACS4; MRX63; MRX68; acyl-CoA synthetase 4; fatty-acid-Coenzyme A ligase; long-chain 4; lignoceroyl-CoA synthase; long-chain fatty-acid-Coenzyme A ligase 4; acyl-CoA synthetase long-chain family member 4]

other names :

[long-chain-fatty-acid--CoA ligase 4 isoform 1; Long-chain-fatty-acid--CoA ligase 4; long-chain-fatty-acid--CoA ligase 4; LACS 4; acyl-CoA synthetase 4; lignoceroyl-CoA synthase; long-chain acyl-CoA synthetase 4; long-chain fatty-acid-Coenzyme A ligase 4; fatty-acid-Coenzyme A ligase, long-chain 4; acyl-CoA synthetase long-chain family member 4; Long-chain acyl-CoA synthetase 4; LACS 4]

products gene name :

[ACSL4]

other gene names :

[ACSL4; ACSL4; ACS4; FACL4; LACS4; MRX63; MRX68; ACS4; FACL4; LACS4; LACS 4]

uniprot entry name :

ACSL4_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: 1.0 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of ACSL4 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

4758332

ncbi acc num :

NP_004449.1

ncbi gb acc num :

NM_004458.2

uniprot acc num :

O60488

ncbi mol weight :

79,188 Da

ncbi pathways :

Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Fatty Acid Beta Oxidation Pathway (198865); Fatty Acid Biosynthesis Pathway (198873); Fatty Acyl-CoA Biosynthesis Pathway (106115); Fatty Acid Metabolism Pathway (82935); Fatty Acid Metabolism Pathway (296); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976)

ncbi summary :

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

uniprot summary :

ACSL4: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates. Defects in ACSL4 are the cause of mental retardation X- linked type 63 (MRX63). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Defects in ACSL4 are involved in Alport syndrome with mental retardation midface hypoplasia and elliptocytosis (ATS-MR). A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, deafness, mental retardation, midface hypoplasia and elliptocytosis. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 6.2.1.3; Ligase; Membrane protein, integral; Lipid Metabolism - fatty acid. Chromosomal Location of Human Ortholog: Xq22.3-q23. Cellular Component: peroxisomal membrane; mitochondrial outer membrane; endoplasmic reticulum membrane; cell soma; membrane; cytoplasm; integral to membrane; lipid particle. Molecular Function: arachidonate-CoA ligase activity; very-long-chain-fatty-acid-CoA ligase activity; ATP binding; long-chain-fatty-acid-CoA ligase activity. Biological Process: lipid biosynthetic process; embryonic process involved in female pregnancy; triacylglycerol biosynthetic process; lipid metabolic process; cellular lipid metabolic process; long-chain fatty acid metabolic process; negative regulation of prostaglandin secretion; positive regulation of cell growth; fatty acid transport; response to nutrient. Disease: Mental Retardation, X-linked 63

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage