ELISA/assay

Human Dual specificity mitogen-activated protein kinase kinase 2, MAP2K2 ELISA Kit

MBS9331134

48-Strip-Wells

470 USD

ELISA Kit

Human Dual specificity mitogen-activated protein kinase kinase 2, MAP2K2 ELISA Kit

[mitogen-activated protein kinase kinase 2]

[Human Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) ELISA kit; FLJ26075; MAPKK2; MEK2; MKK2; PRKMK2; ERK activator kinase 2; MAP kinase kinase 2; MAPK/ERK kinase 2; dual specificity mitogen-activated protein kinase kinase 2; mitogen-activated protein kinase kinase; mitogen-activated protein kinase kinase 2]

[dual specificity mitogen-activated protein kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 2; dual specificity mitogen-activated protein kinase kinase 2; MAPK/ERK kinase 2; MAP kinase kinase 2; ERK activator kinase 2; mitogen-activated protein kinase kinase 2, p45; mitogen-activated protein kinase kinase 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2]

[MAP2K2]

[MAP2K2; MAP2K2; CFC4; MEK2; MKK2; MAPKK2; PRKMK2; MEK2; MKK2; PRKMK2; MAP kinase kinase 2; MAPKK 2; MEK 2]

MP2K2_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of MAP2K2 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

13489054

NP_109587.1

NM_030662.3

P36507

44,424 Da

ARMS-mediated Activation Pathway (106466); Activated TLR4 Signalling Pathway (106400); Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Axon Guidance Pathway (105688); B Cell Receptor Signaling Pathway (198909); B Cell Receptor Signaling Pathway (83081); B Cell Receptor Signaling Pathway (492); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527)

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]

MEK2: a dual-specificity protein kinase of the STE7 kinase family. Phosphorylated and activated by Raf and Mos kinases. Phosphorylates a Thr and a Tyr residue in a Thr-Glu-Tyr sequence located in the activation loop of ERK2 and ERK3. A component of MAP kinase signal transduction pathways involved in mitogen growth factor signal transduction. Protein type: Kinase, protein; Protein kinase, STE; EC 2.7.12.2; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: peroxisomal membrane; Golgi apparatus; microtubule; internal side of plasma membrane; focal adhesion; mitochondrion; endoplasmic reticulum; early endosome; extracellular region; intercellular junction; cell cortex; cytosol; perinuclear region of cytoplasm; late endosome; cytoplasm; nucleus. Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; protein serine/threonine/tyrosine kinase activity; protein complex scaffold; ATP binding; PDZ domain binding. Biological Process: epidermal growth factor receptor signaling pathway; axon guidance; peptidyl-tyrosine phosphorylation; fibroblast growth factor receptor signaling pathway; activation of MAPKK activity; nerve growth factor receptor signaling pathway; activation of MAPK activity; MyD88-independent toll-like receptor signaling pathway; MAPKKK cascade; stress-activated MAPK cascade; pathogenesis; toll-like receptor 3 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of stress-activated MAPK cascade; small GTPase mediated signal transduction; Ras protein signal transduction; toll-like receptor signaling pathway; insulin receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; vascular endothelial growth factor receptor signaling pathway; toll-like receptor 4 signaling pathway. Disease: Cardiofaciocutaneous Syndrome 4

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095