catalog number :
MBS9330948
products type :
ELISA Kit
products full name :
Human Short transient receptor potential channel 6, TRPC6 ELISA Kit
products short name :
transient receptor potential cation channel, subfamily C, member 6
products name syn :
Human Short transient receptor potential channel 6 (TRPC6) ELISA kit; FLJ11098; FLJ14863; FSGS2; TRP6; ; transient receptor potential cation channel; subfamily C; member 6
other names :
short transient receptor potential channel 6; Short transient receptor potential channel 6; short transient receptor potential channel 6; TRP-6; transient receptor protein 6; focal segmental glomerulosclerosis 2; transient receptor potential cation channel, subfamily C, member 6; Transient receptor protein 6; TRP-6
products gene name :
TRPC6
other gene names :
TRPC6; TRPC6; TRP6; FSGS2; TRP6; TrpC6; TRP-6
uniprot entry name :
TRPC6_HUMAN
ncbi acc num :
NP_004612.2
ncbi gb acc num :
NM_004621.5
ncbi mol weight :
106,326 Da
ncbi pathways :
Axon Guidance Pathway 105688!!Developmental Biology Pathway 477129!!EPO Signaling Pathway 138051!!Effects Of PIP2 Hydrolysis Pathway 106044!!Elevation Of Cytosolic Ca2+ Levels Pathway 106047!!Endothelins Pathway 137958!!G Alpha (q) Signalling Events Pathway 106043!!GPCR Downstream Signaling Pathway 119548!!Hemostasis Pathway 106028!!Nephrin/Neph1 Signaling In The Kidney Podocyte Pathway 138072
ncbi summary :
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]
uniprot summary :
Function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.