catalog number :
MBS9330506
products type :
ELISA Kit
products full name :
Human Sialic acid-binding Ig-like lectin 7, SIGLEC7 ELISA Kit
products short name :
[sialic acid binding Ig-like lectin 7]
products name syn :
[Human Sialic acid-binding Ig-like lectin 7 (SIGLEC7) ELISA kit; AIRM1; CD328; CDw328; D-siglec; QA79; SIGLEC-7; p75; p75/AIRM1; adhesion inhibitory receptor molecule 1; siglec-7; sialic acid binding immunoglobulin-like lectin 7; sialic acid binding Ig-like lectin 7]
other names :
[sialic acid-binding Ig-like lectin 7 isoform 3; Sialic acid-binding Ig-like lectin 7; sialic acid-binding Ig-like lectin 7; AIRM-1; QA79 membrane protein; sialic acid binding immunoglobulin-like lectin 7; adhesion inhibitory receptor molecule 1, siglec-7; sialic acid binding Ig-like lectin 7; Adhesion inhibitory receptor molecule 1; AIRM-1; CDw328; D-siglec; QA79 membrane protein; p75; CD_antigen: CD328]
products gene name :
[SIGLEC7]
other gene names :
[SIGLEC7; SIGLEC7; p75; QA79; AIRM1; CD328; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1; AIRM1; Siglec-7; AIRM-1]
uniprot entry name :
SIGL7_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of SIGLEC7 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_001264130.1
ncbi gb acc num :
NM_001277201.1
ncbi mol weight :
51,143 Da
uniprot summary :
SIGLEC7: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Cell adhesion; Membrane protein, integral. Chromosomal Location of Human Ortholog: 19q13.3. Cellular Component: integral to plasma membrane. Molecular Function: receptor activity; carbohydrate binding. Biological Process: cell adhesion
size4 :
10x96-Strip-Wells