ELISA/assay

Human Serine/threonine-protein kinase PAK 1, PAK1 ELISA Kit

MBS9330410

96 Strip Wells

600 USD

ELISA Kit

Human Serine/threonine-protein kinase PAK 1, PAK1 ELISA Kit

p21 protein (Cdc42/Rac) -activated kinase 1

Human Serine/threonine-protein kinase PAK 1 (PAK1) ELISA kit; MGC130000; MGC130001; PAKalpha; STE20 homolog; yeast; p21-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog; yeast) ; p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related) ; p21 protein (Cdc42/Rac) -activated kinase 1

serine/threonine-protein kinase PAK 1 isoform 1; Serine/threonine-protein kinase PAK 1; serine/threonine-protein kinase PAK 1; p65-PAK; alpha-PAK; STE20 homolog, yeast; p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21 protein (Cdc42/Rac)-activated kinase 1; Alpha-PAK; p21-activated kinase 1; PAK-1; p65-PAK

PAK1

PAK1; PAK1; PAKalpha; PAK-1

PAK1_HUMAN

Human

190886457

NP_001122092.1

NM_001128620.1

Q13153

60,647 Da

Activation Of Rac Pathway 119530!!Adaptive Immune System Pathway 366160!!Alpha6-Beta4 Integrin Signaling Pathway 198807!!Angiopoietin Receptor Tie2-mediated Signaling Pathway 137917!!Aurora A Signaling Pathway 137925!!Axon Guidance Pathway 83065!!Axon Guidance Pathway 476!!Axon Guidance Pathway 105688!!CD28 Co-stimulation Pathway 119553!!CD28 Dependent Vav1 Pathway 119555

This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

Function: Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2. Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus. In podocytes, promotes NR3C2 nuclear localization. Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation.17 PublicationsManual assertion based on experiment in:Ref.1. Catalytic activity: ATP + a protein = ADP + a phosphoprotein.3 PublicationsManual assertion based on experiment in:Ref.6. Cofactor: Magnesium. Enzyme regulation: Phosphorylation of Thr-84 by OXSR1 inhibits activation Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, and enables activation by phosphorylation of Thr-423.4 PublicationsManual assertion based on experiment in:Ref.6

96 Strip Wells

600 USD