Mouse Histone-lysine N-methyltransferase MLL5, MLL5 ELISA Kit | MyBioSource MBS9330243 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse Histone-lysine N-methyltransferase MLL5, MLL5 ELISA Kit

catalog :

MBS9330243

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9330243

products type :

ELISA Kit

products full name :

Mouse Histone-lysine N-methyltransferase MLL5, MLL5 ELISA Kit

products short name :

[myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)]

products name syn :

[Mouse Histone-lysine N-methyltransferase MLL5 (MLL5) ELISA kit; FLJ10078; FLJ14026; HDCMC04P; KMT2E; MGC70452; myeloid/lymphoid or mixed-lineage leukemia 5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog; Drosophila)]

other names :

[histone-lysine N-methyltransferase 2E; Histone-lysine N-methyltransferase 2E; histone-lysine N-methyltransferase 2E; histone-lysine N-methyltransferase MLL5; myeloid/lymphoid or mixed-lineage leukemia 5; myeloid/lymphoid or mixed-lineage leukemia protein 5 homolog; lysine (K)-specific methyltransferase 2E; Myeloid/lymphoid or mixed-lineage leukemia protein 5 homolog]

products gene name :

[MLL5]

other gene names :

[Kmt2e; Kmt2e; Mll5; NKp44L; 1810033J14Rik; 9530077A04Rik; D230038D11Rik; Mll5; Lysine N-methyltransferase 2E]

uniprot entry name :

KMT2E_MOUSE

reactivity :

Mouse

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. Assay Type: Sandwich (Quantitative). Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of MLL5 (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

262527254

ncbi acc num :

NP_081260.1

ncbi gb acc num :

NM_026984.1

uniprot acc num :

Q3UG20

ncbi mol weight :

204,543 Da

ncbi pathways :

Lysine Degradation Pathway (83156); Lysine Degradation Pathway (320)

uniprot summary :

MLL5: Histone methyltransferase that specifically mono- and dimethylates Lys-4 of histone H3 (H3K4me1 and H3K4me2). H3 Lys- 4 methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic- acid-induced granulopoiesis by acting as a coactivator of RAR- alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases. Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily. 7 isoforms of the human protein are produced by alternative splicing. Protein type: EC 2.1.1.43; Methyltransferase, protein lysine; Methyltransferase; Cell cycle regulation; Transcription, coactivator/corepressor. Cellular Component: nucleoplasm; intercellular bridge; intracellular membrane-bound organelle; nucleus. Molecular Function: transferase activity; methyltransferase activity; enzyme binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K4 specific); metal ion binding; transcription coactivator activity; histone-lysine N-methyltransferase activity. Biological Process: methylation; retinoic acid receptor signaling pathway; neutrophil activation; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; histone H3-K4 methylation; positive regulation of granulocyte differentiation; neutrophil mediated immunity; chromatin modification; cell cycle; peptidyl-lysine methylation; regulation of transcription, DNA-dependent; DNA methylation; erythrocyte differentiation; cell cycle arrest

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage