catalog number :
MBS9330027
products type :
ELISA Kit
products full name :
Human TSC22 domain family protein 3, TSC22D3 ELISA Kit
products short name :
[TSC22 domain family, member 3]
products name syn :
[Human TSC22 domain family protein 3 (TSC22D3) ELISA kit; RP13-364K23.1; DIP; DKFZp313A1123; DSIPI; GILZ; TSC-22R; hDIP; DSIP-immunoreactive leucine zipper protein; OTTHUMP00000023814; TSC-22 related protein; delta sleep inducing peptide; immunoreactor; glucoc; TSC22 domain family; member 3]
other names :
[TSC22 domain family protein 3 isoform 3; TSC22 domain family protein 3; TSC22 domain family protein 3; TSC-22-like protein; TSC-22 related protein; TSC-22-related protein; DSIP-immunoreactive peptide; DSIP-immunoreactive leucine zipper protein; delta sleep-inducing peptide immunoreactor; delta sleep inducing peptide, immunoreactor; glucocorticoid-induced leucine zipper protein; TSC22 domain family, member 3; DSIP-immunoreactive peptide; Protein DIP; hDIP; Delta sleep-inducing peptide immunoreactor; Glucocorticoid-induced leucine zipper protein; GILZ; TSC-22-like protein; TSC-22-related protein; TSC-22R]
products gene name :
[TSC22D3]
other gene names :
[TSC22D3; TSC22D3; DIP; GILZ; hDIP; DSIPI; TSC-22R; DSIPI; GILZ; Protein DIP; hDIP; GILZ; TSC-22R]
uniprot entry name :
T22D3_HUMAN
storage stability :
Store all reagents at 2-8 degree C
ncbi acc num :
NP_001015881.1
ncbi gb acc num :
NM_001015881.1
ncbi mol weight :
14,810 Da
ncbi summary :
The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. The expression of this gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
uniprot summary :
GILZ: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Belongs to the TSC-22/Dip/Bun family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding. Chromosomal Location of Human Ortholog: Xq22.3. Cellular Component: cytosol; nucleus. Molecular Function: MRF binding; transcription factor activity. Biological Process: negative regulation of skeletal muscle development; regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; body fluid secretion; response to osmotic stress; transmembrane transport
size4 :
10x96-Strip-Wells