ELISA/assay

Mouse Nucleotide-binding oligomerization domain-containing protein 2, NOD2 ELISA Kit

MBS932989

48-Strip-Wells

510 USD

ELISA Kit

Mouse Nucleotide-binding oligomerization domain-containing protein 2, NOD2 ELISA Kit

nucleotide-binding oligomerization domain containing 2

Mouse Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) ELISA kit; ACUG; BLAU; CARD15; CD; CLR16.3; IBD1; NLRC2; NOD2B; PSORAS1; NLR family; CARD domain containing 2; NOD-like receptor C2; caspase recruitment domain family; member 15; caspase recruitment domain protei; nucleotide-binding oligomerization domain containing 2

Nucleotide-binding oligomerization domain-containing protein 2; Nucleotide-binding oligomerization domain-containing protein 2; nucleotide-binding oligomerization domain-containing protein 2; caspase recruitment domain family, member 15; caspase recruitment domain-containing protein 15; nucleotide-binding oligomerization domain containing 2; Caspase recruitment domain-containing protein 15

NOD2

Nod2; Nod2; CD; ACUG; BLAU; IBD1; Nlrc2; Card15; F830032C23Rik; Card15

NOD2_MOUSE

Mouse

1020

This assay has high sensitivity and excellent specificity for detection of Mouse NOD2. No significant cross-reactivity or interference between Mouse NOD2 and analogues was observed.

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Samples: Serum, plasma, tissue homogenates, Cell lysates. Detection Range: 15.6 pg/ml-1000 pg/ml. Sensitivity: 3.9 pg/ml

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul

29427819

Q8K3Z0.1

Q8K3Z0

113,562 Da

Activated TLR4 Signalling Pathway (970703); Cytokine Signaling In Immune System Pathway (970814); Immune System Pathway (971216); Inflammatory Bowel Disease (IBD) Pathway (842778); Inflammatory Bowel Disease (IBD) Pathway (842797); Innate Immune System Pathway (971212); Interleukin-1 Signaling Pathway (1001288); JNK (c-Jun Kinases) Phosphorylation And Activation Mediated By Activated Human TAK1 Pathway (1001214); MAP Kinase Activation In TLR Cascade Pathway (970472); MyD88 Cascade Initiated On Plasma Membrane Pathway (1001210)

NOD2: Induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK- gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Defects in NOD2 are the cause of Blau syndrome (BS). BS is a rare autosomal dominant disorder characterized by early-onset granulomatous arthritis, uveitis and skin rash. Defects in NOD2 are a cause of susceptibility to inflammatory bowel disease type 1 (IBD1). IBD1 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Defects in NOD2 are the cause of sarcoidosis early-onset (EOS). EOS is a form of sarcoidosis manifesting in children younger than 4 years of age. Sarcoidosis is an idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Early- onset sarcoidosis is quite rare and has a distinct triad of skin, joint and eye disorders, without apparent pulmonary involvement. Compared with an asymptomatic and sometimes naturally disappearing course of the disease in older children, early-onset sarcoidosis is progressive and in many cases causes severe complications, such as blindness, joint destruction and visceral involvement. 2 isoforms of the human protein are produced by alternative initiation. Cellular Component: signalosome; cell surface; protein complex; cytoskeleton; cytoplasm; plasma membrane; intracellular; cytosol; vesicle. Molecular Function: endodeoxyribonuclease activity, producing 5 -phosphomonoesters; peptidoglycan binding; protein binding; enzyme binding; nucleotide binding; CARD domain binding; protein kinase binding; ATP binding; muramyl dipeptide binding. Biological Process: maintenance of gastrointestinal epithelium; positive regulation of dendritic cell antigen processing and presentation; response to lipopolysaccharide; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-10 production; negative regulation of interleukin-2 production; activation of NF-kappaB transcription factor; regulation of apoptosis; positive regulation of phagocytosis; detection of muramyl dipeptide; cytokine production during immune response; detection of biotic stimulus; positive regulation of oxidoreductase activity; positive regulation of interleukin-17 production; negative regulation of interleukin-12 production; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of T-helper 2 type immune response; positive regulation of dendritic cell cytokine production; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; protein oligomerization; negative regulation of interleukin-18 production; defense response to Gram-positive bacterium; positive regulation of peptidyl-tyrosine phosphorylation; innate immune response in mucosa; response to muramyl dipeptide; inhibition of NF-kappaB transcription factor; positive regulation of B cell activation; defense response to bacterium; positive regulation of transcription from RNA polymerase II promoter; negative regulation of T cell mediated immunity; positive regulation of epithelial cell proliferation; positive regulation of nitric-oxide synthase biosynthetic process; activation of immune response; detection of bacterium; positive regulation of interleukin-12 production; positive regulation of JNK cascade; defense response; signal transduction; positive regulation of stress-activated MAPK cascade; response to exogenous dsRNA; positive regulation of MAPKKK cascade; negative regulation of interferon-gamma production; response to peptidoglycan; positive regulation of cell proliferation; positive regulation of innate immune response; negative regulation of inflammatory response to antigenic stimulus; positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria; inflammatory response; positive regulation of Notch signaling pathway; positive regulation of humoral immune response mediated by circulating immunoglobulin; immune system process; positive regulation of antibacterial peptide biosynthetic process; negative regulation of toll-like receptor 2 signaling pathway; positive regulation of phosphoinositide 3-kinase activity; negative regulation of tumor necrosis factor production; immunoglobulin production during immune response; positive regulation of interleukin-1 beta production; positive regulation of protein ubiquitination; regulation of inflammatory response; innate immune response

48-Strip-Wells

510 USD

96-Strip-Wells

725

5x96-Strip-Wells

2565

10x96-Strip-Wells

4800