ELISA/assay

Mouse Porphobilinogen deaminase, HMBS ELISA Kit

MBS9329275

48-Strip-Wells

435 USD

ELISA Kit

Mouse Porphobilinogen deaminase, HMBS ELISA Kit

Porphobilinogen deaminase, HMBS ELISA Kit

Hydroxymethylbilane synthase; Mouse Porphobilinogen deaminase (HMBS) ELISA kit; PBG-D; PBGD; UPS; porphobilinogen deaminase; pre-uroporphyrinogen synthase; uroporphyrinogen I synthase; uroporphyrinogen I synthetase; hydroxymethylbilane synthase

porphobilinogen deaminase isoform 1; Porphobilinogen deaminase; porphobilinogen deaminase; PBG-D; pre-uroporphyrinogen synthase; hydroxymethylbilane synthase; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

HMBS

Hmbs; Hmbs; Ups; PBGD; Uros1; T25658; Uros1; PBG-D; HMBS

HEM3_MOUSE

Mouse

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of HMBS (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

159110431

NP_038579.2

NM_013551.2

P22907

39,344 Da

Heme Biosynthesis Pathway (198305); Heme Biosynthesis Pathway (574886); Metabolism Pathway (574739); Metabolism Of Porphyrins Pathway (574885); Porphyrin And Chlorophyll Metabolism Pathway (83219); Porphyrin And Chlorophyll Metabolism Pathway (407); Heme Biosynthesis II Pathway (542887); Tetrapyrrole Biosynthesis II Pathway (142880)

HMBS: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Defects in HMBS are the cause of acute intermittent porphyria (AIP). AIP is a form of porphyria. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. AIP is an autosomal dominant form of hepatic porphyria characterized by acute attacks of neurological dysfunctions with abdominal pain, hypertension, tachycardia, and peripheral neuropathy. Most attacks are precipitated by drugs, alcohol, caloric deprivation, infections, or endocrine factors. Belongs to the HMBS family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Mitochondrial; EC 2.5.1.61; Transferase; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll. Cellular Component: axon; cytoplasm; condensed chromosome; nucleus. Molecular Function: transferase activity; amine binding; carboxylic acid binding; uroporphyrinogen-III synthase activity; coenzyme binding; hydroxymethylbilane synthase activity. Biological Process: tetrapyrrole biosynthetic process; peptidyl-pyrromethane cofactor linkage; porphyrin biosynthetic process; heme biosynthetic process

48-Strip-Wells

435 USD

96-Strip-Wells

600