catalog number :
MBS9328886
products type :
ELISA Kit
products full name :
Mouse DediCator of cytokinesis protein 2, DOCK2 ELISA Kit
products short name :
[dedicator of cytokinesis 2]
products name syn :
[Mouse Dedicator of cytokinesis protein 2 (DOCK2) ELISA kit; FLJ46592; KIAA0209; dedicator of cyto-kinesis 2; dedicator of cytokinesis 2]
other names :
[dedicator of cytokinesis protein 2; Dedicator of cytokinesis protein 2; dedicator of cytokinesis protein 2; dedicator of cyto-kinesis 2; Protein Hch]
products gene name :
[DOCK2]
other gene names :
[Dock2; Dock2; Hch; MBC; CED-5; AI662014; AW122239]
uniprot entry name :
DOCK2_MOUSE
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of DOCK2 (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_203538.2
ncbi gb acc num :
NM_033374.3
ncbi mol weight :
211,704 Da
ncbi pathways :
Chemokine Signaling Pathway (99271); Chemokine Signaling Pathway (96864); Fc Gamma R-mediated Phagocytosis Pathway (114297); Fc Gamma R-mediated Phagocytosis Pathway (106590); T Cell Receptor Signaling Pathway (198362)
uniprot summary :
DOCK2: a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis. Plays a role in T cell receptor-induced activation of Rac2 and IL-2 transcription. Interacts with RAC, CRKL, and CD3-zeta. Association with ELMO1 is critical for DOCK2-mediated Rac activation. Two alternatively-spliced isoforms have been described. Protein type: Motility/polarity/chemotaxis; GAPs; GAPs, Rac/Rho; Adaptor/scaffold. Cellular Component: cytoskeleton; membrane; cytoplasm. Molecular Function: guanyl-nucleotide exchange factor activity; Rac guanyl-nucleotide exchange factor activity; T cell receptor binding; GTPase activator activity. Biological Process: alpha-beta T cell proliferation; formation of immunological synapse; T cell activation; myeloid dendritic cell activation during immune response; cytoskeleton organization and biogenesis; alpha-beta T cell activation; chemotaxis; negative thymic T cell selection; T cell proliferation; positive regulation of Rac protein signal transduction; positive regulation of phagocytosis; small GTPase mediated signal transduction; establishment of T cell polarity; lipid raft polarization; positive thymic T cell selection; positive regulation of GTPase activity
size4 :
10x96-Strip-Wells