Human MHC class II transactivator, CIITA ELISA Kit | MyBioSource MBS9328686 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human MHC class II transactivator, CIITA ELISA Kit

catalog :

MBS9328686

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9328686

products type :

ELISA Kit

products full name :

Human MHC class II transactivator, CIITA ELISA Kit

products short name :

[class II, major histocompatibility complex, transactivator]

products name syn :

[Human MHC class II transactivator (CIITA) ELISA kit; C2TA; CIITAIV; MHC2TA; NLRA; MHC class II transactivator type III; NLR family; acid domain containing; class II transactivator; nucleotide-binding oligomerization domain; leucine rich repeat and acid d; class II; major histocompatibility complex; transactivator]

other names :

[MHC class II transactivator isoform 2; MHC class II transactivator; MHC class II transactivator; NLR family, acid domain containing; MHC class II transactivator type III; nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing; class II, major histocompatibility complex, transactivator]

products gene name :

[CIITA]

other gene names :

[CIITA; CIITA; C2TA; NLRA; MHC2TA; CIITAIV; MHC2TA; CIITA]

uniprot entry name :

C2TA_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Human Serum, Plasma Or Tissue Homogenates Samples. Assay Type: Quantitative Sandwich. Detection Range: 0.625ng/ml-20ng/ml. Sensitivity: 0.1ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determine the level of CIIC (hereafter termed "analyte") in undiluted original Human serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

ncbi gi num :

156938336

ncbi acc num :

NP_000237.2

ncbi gb acc num :

NM_000246.3

uniprot acc num :

P33076

ncbi mol weight :

123,514 Da

ncbi pathways :

Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Cytokine Signaling In Immune System Pathway (366171); Immune System Pathway (106386); Influenza A Pathway (217173); Influenza A Pathway (217150); Interferon Signaling Pathway (187103); Interferon Gamma Signaling Pathway (187106); Primary Immunodeficiency Pathway (83125); Primary Immunodeficiency Pathway (537)

ncbi summary :

This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

uniprot summary :

CIITA: a non-DNA binding transactivator that functions both in constitutive and inducible MHC Class II expression. Defects are a cause of bare lymphocyte syndrome type II (BLS II), a form of severe combined immunodeficiency disease (SCID) characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, an absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. Protein type: DNA-binding; Transcription, coactivator/corepressor; EC 2.7.11.1. Chromosomal Location of Human Ortholog: 16p13. Cellular Component: nucleoplasm; PML body. Molecular Function: protein C-terminus binding; protein binding; DNA binding; transcription activator binding; GTP binding; transcription coactivator activity; protein complex binding; transferase activity, transferring acyl groups; kinase activity; ATP binding. Biological Process: response to antibiotic; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of transcription, DNA-dependent; positive regulation of MHC class II biosynthetic process; negative regulation of collagen biosynthetic process; immune response; positive regulation of MHC class I biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; phosphorylation. Disease: Rheumatoid Arthritis; Bare Lymphocyte Syndrome, Type Ii

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage