Human Homeobox protein Nkx-3.1, NKX3-1 ELISA Kit | MyBioSource MBS9328550 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Homeobox protein Nkx-3.1, NKX3-1 ELISA Kit

catalog :

MBS9328550

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS9328550

products type :

ELISA Kit

products full name :

Human Homeobox protein Nkx-3.1, NKX3-1 ELISA Kit

products short name :

[NK3 homeobox 1]

products name syn :

[Human Homeobox protein Nkx-3.1 (NKX3-1) ELISA kit; BAPX2; NKX3; NKX3.1; NKX3A; NK homeobox; family 3; A; NK3 transcription factor homolog A; NK3 transcription factor related; locus 1; NK3 homeobox 1]

other names :

[homeobox protein Nkx-3.1 isoform 2; Homeobox protein Nkx-3.1; homeobox protein Nkx-3.1; NK homeobox, family 3, A; homeobox protein NK-3 homolog A; NK3 transcription factor homolog A; NK3 transcription factor related, locus 1; NK3 homeobox 1; Homeobox protein NK-3 homolog A]

products gene name :

[NKX3-1]

other gene names :

[NKX3-1; NKX3-1; NKX3; BAPX2; NKX3A; NKX3.1; NKX3.1; NKX3A]

uniprot entry name :

NKX31_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of NKX3-1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

373432628

ncbi acc num :

NP_001243268.1

ncbi gb acc num :

NM_001256339.1

uniprot acc num :

Q99801

ncbi mol weight :

26,350 Da

ncbi pathways :

Coregulation Of Androgen Receptor Activity Pathway (138085); FOXA1 Transcription Factor Network Pathway (137979); Pathways In Cancer (83105); Prostate Cancer Pathway (83111); Prostate Cancer Pathway (523); SIDS Susceptibility Pathways (198901)

ncbi summary :

This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]

uniprot summary :

NKX3-1: Transcription factor, which binds preferentially the consensus sequence 5 -TAAGT[AG]-3 and can behave as a transcriptional repressor. Play an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Act as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. Interacts with serum response factor (SRF). Interacts with SPDEF. Interacts with WDR77. Interacts with TOPORS which polyubiquitinates NKX3-1 and induces its proteasomal degradation. By androgens and, in the LNCAP cell line, by estrogens. Androgenic control may be lost in prostate cancer cells during tumor progression from an androgen-dependent to an androgen- independent phase. Highly expressed in the prostate and, at a lower level, in the testis. Belongs to the NK-3 homeobox family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Tumor suppressor; DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 8p21.2. Cellular Component: intracellular; nucleus. Molecular Function: androgen receptor activity; protein binding; estrogen receptor activity; protein self-association; sequence-specific DNA binding; histone deacetylase binding; estrogen receptor binding; caspase activator activity; transcription factor binding; protein kinase activator activity; transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; salivary gland development; multicellular organismal development; heart development; positive regulation of transcription, DNA-dependent; negative regulation of insulin-like growth factor receptor signaling pathway; positive regulation of caspase activity; positive regulation of mitotic cell cycle; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; protein kinase B signaling cascade; negative regulation of mitotic cell cycle; negative regulation of epithelial cell proliferation; caspase activation; somitogenesis; pharyngeal system development; male gonad development; response to testosterone stimulus; positive regulation of phosphoinositide 3-kinase cascade; branching morphogenesis of a tube; positive regulation of cell division; positive regulation of protein kinase activity; androgen receptor signaling pathway; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; negative regulation of transcription, DNA-dependent; metanephros development

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095