Human DNA-directed RNA polymerase III subunit RPC4, POLR3D ELISA Kit | MyBioSource MBS9328545 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human DNA-directed RNA polymerase III subunit RPC4, POLR3D ELISA Kit

catalog :

MBS9328545

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9328545

products type :

ELISA Kit

products full name :

Human DNA-directed RNA polymerase III subunit RPC4, POLR3D ELISA Kit

products short name :

[polymerase (RNA) III (DNA directed) polypeptide D, 44kDa]

products name syn :

[Human DNA-directed RNA polymerase III subunit RPC4 (POLR3D) ELISA kit; BN51T; RPC4; RPC53; TSBN51; BN51 (BHK21) temperature sensitivity complementing; polymerase (RNA) III (DNA directed) polypeptide D; temperature sensitive complementation; cell cycle specific; tsBN51; polymerase (RNA) III (DNA directed) polypeptide D; 44kDa]

other names :

[DNA-directed RNA polymerase III subunit RPC4; DNA-directed RNA polymerase III subunit RPC4; DNA-directed RNA polymerase III subunit RPC4; RPC53 homolog; RNA polymerase III subunit C4; RNA polymerase III 47 kDa subunit; DNA-directed RNA polymerase III subunit D; BN51 (BHK21) temperature sensitivity complementing; DNA-directed RNA polymerase III 47 kDa polypeptide; temperature sensitive complementation, cell cycle specific, tsBN51; polymerase (RNA) III (DNA directed) polypeptide D, 44kDa; DNA-directed RNA polymerase III subunit D; Protein BN51; RNA polymerase III 47 kDa subunit; RPC53 homolog]

products gene name :

[POLR3D]

other gene names :

[POLR3D; POLR3D; RPC4; BN51T; RPC53; TSBN51; BN51; BN51T; RNA polymerase III subunit C4]

uniprot entry name :

RPC4_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Serum, Plasma and Tissue Homogenate. Assay Type: Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: 1.0 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of POLR3D (hereafter termed this analyte) in undiluted original Human serum, plasma and tissue homogenate samples.

ncbi gi num :

55769552

ncbi acc num :

NP_001713.2

ncbi gb acc num :

NM_001722.2

uniprot acc num :

P05423

ncbi mol weight :

44,396 Da

ncbi pathways :

Cytosolic DNA-sensing Pathway (125137); Cytosolic DNA-sensing Pathway (124833); Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115); Eukaryotic Transcription Initiation Pathway (198917); Gene Expression Pathway (105937); Purine Metabolism Pathway (82944); Purine Metabolism Pathway (307); Pyrimidine Metabolism Pathway (82946); Pyrimidine Metabolism Pathway (309)

ncbi summary :

This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. [provided by RefSeq, Jul 2008]

uniprot summary :

POLR3D: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Belongs to the eukaryotic RPC4/POLR3D RNA polymerase subunit family. Protein type: Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine. Chromosomal Location of Human Ortholog: 8q21. Cellular Component: nucleoplasm; DNA-directed RNA polymerase III complex; nuclear chromatin; cytoplasm; cytosol. Molecular Function: DNA binding; chromatin binding. Biological Process: transcription from RNA polymerase III promoter; termination of RNA polymerase III transcription; positive regulation of innate immune response; positive regulation of interferon-beta production; positive regulation of interferon type I production; innate immune response; gene expression; defense response to virus; RNA elongation from RNA polymerase III promoter

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage