Human Tumor necrosis factor ligand superfamily member 9, TNFSF9 ELISA Kit | MyBioSource MBS932847 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Tumor necrosis factor ligand superfamily member 9, TNFSF9 ELISA Kit

catalog :

MBS932847

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS932847

products type :

ELISA Kit

products full name :

Human Tumor necrosis factor ligand superfamily member 9, TNFSF9 ELISA Kit

products short name :

tumor necrosis factor (ligand) superfamily, member 9

products name syn :

Human Tumor necrosis factor ligand superfamily member 9 (TNFSF9) ELISA kit; 4-1BB-L; CD137L; homolog of mouse 4-1BB-L; receptor 4-1BB ligand; tumor necrosis factor (ligand) superfamily; member 9

other names :

tumor necrosis factor ligand superfamily member 9; Tumor necrosis factor ligand superfamily member 9; tumor necrosis factor ligand superfamily member 9; 4-1BBL; 4-1BB ligand; receptor 4-1BB ligand; homolog of mouse 4-1BB-L; tumor necrosis factor (ligand) superfamily, member 9; 4-1BB ligand; 4-1BBL

products gene name :

TNFSF9

other gene names :

TNFSF9; TNFSF9; CD137L; 4-1BB-L; 4-1BBL

uniprot entry name :

TNFL9_HUMAN

reactivity :

Human

sequence length :

254

specificity :

This assay has high sensitivity and excellent specificity for detection of Human TNFSF9. No significant cross-reactivity or interference between Human TNFSF9 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, tissue homogenates. Assay Type: Sandwich. Detection Range: 18.75 pg/ml-1200 pg/ml. Sensitivity: 4.68 pg/ml

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul

products description :

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for TNFSF9 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any TNFSF9 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for TNFSF9 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of TNFSF9 bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

4507609

ncbi acc num :

NP_003802.1

ncbi gb acc num :

NM_003811.3

uniprot acc num :

P41273

ncbi mol weight :

26,625 Da

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460)

ncbi summary :

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]

uniprot summary :

TNFL9: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. Belongs to the tumor necrosis factor family. Protein type: Cell cycle regulation; Apoptosis; Cytokine; Membrane protein, integral. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: extracellular space; integral to membrane; plasma membrane. Molecular Function: cytokine activity; tumor necrosis factor receptor binding; receptor binding. Biological Process: cell proliferation; positive regulation of interferon-gamma production; positive regulation of cytotoxic T cell differentiation; cell-cell signaling; positive regulation of interleukin-12 production; apoptosis; positive regulation of interleukin-6 production; myeloid dendritic cell differentiation; immune response; positive regulation of activated T cell proliferation; signal transduction

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage