catalog number :
MBS9328323
products type :
ELISA Kit
products full name :
Human Sodium- and chloride-dependent GABA transporter 1, SLC6A1 ELISA Kit
products short name :
[solute carrier family 6 (neurotransmitter transporter, GABA) , member 1]
products name syn :
[Human Sodium- and chloride-dependent GABA transporter 1 (SLC6A1) ELISA kit; GABATHG; GABATR; GAT1; ; solute carrier family 6 (neurotransmitter transporter; GABA); member 1]
other names :
[sodium- and chloride-dependent GABA transporter 1; Sodium- and chloride-dependent GABA transporter 1; sodium- and chloride-dependent GABA transporter 1; GAT-1; solute carrier family 6 member 1; solute carrier family 6 (neurotransmitter transporter, GABA), member 1; solute carrier family 6 (neurotransmitter transporter), member 1; Solute carrier family 6 member 1]
products gene name :
[SLC6A1]
other gene names :
[SLC6A1; SLC6A1; GAT1; GABATR; GABATHG; GABATR; GABT1; GAT1; GAT-1]
uniprot entry name :
SC6A1_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 0.625 ng/ml - 20 ng/mL. Sensitivity: 0.1 ng/mL
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of SLC6A1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_003033.3
ncbi gb acc num :
NM_003042.3
ncbi mol weight :
67,074 Da
ncbi pathways :
GABA Synthesis, Release, Reuptake And Degradation Pathway (187174); GABAergic Synapse Pathway (377263); GABAergic Synapse Pathway (377129); Monoamine Transport Pathway (198851); Na+/Cl- Dependent Neurotransmitter Transporters Pathway (161070); Neuronal System Pathway (106513); Neurotransmitter Release Cycle Pathway (106518); Reuptake Of GABA Pathway (187176); SLC-mediated Transmembrane Transport Pathway (119558); Transmembrane Transport Of Small Molecules Pathway (106572)
ncbi summary :
The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009]
uniprot summary :
SLC6A1: Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily. Protein type: Membrane protein, multi-pass; Transporter; Transporter, SLC family; Membrane protein, integral. Chromosomal Location of Human Ortholog: 3p25.3. Cellular Component: cell surface; membrane; axon; integral to plasma membrane; plasma membrane; integral to membrane. Molecular Function: gamma-aminobutyric acid:sodium symporter activity; neurotransmitter:sodium symporter activity. Biological Process: response to purine; neurotransmitter secretion; response to toxin; learning; response to cocaine; response to estradiol stimulus; response to sucrose stimulus; synaptic transmission; transport; response to lead ion; gamma-aminobutyric acid import; negative regulation of synaptic transmission, GABAergic; response to calcium ion; transmembrane transport; protein homooligomerization; positive regulation of gamma-aminobutyric acid secretion. Disease: Myoclonic-atonic Epilepsy
size4 :
10x96-Strip-Wells