catalog number :
MBS9327515
products type :
ELISA Kit
products full name :
Human ERO1-like protein beta, ERO1LB ELISA Kit
products short name :
ERO1-like beta (S. cerevisiae)
products name syn :
Human ERO1-like protein beta (ERO1LB) ELISA kit; DKFZp779C1042; DKFZp779I0141; FLJ11003; endoplasmic reticulum oxidoreductin 1-Lbeta; ERO1-like beta (S. cerevisiae)
other names :
ERO1-like protein beta; ERO1-like protein beta; ERO1-like protein beta; ERO1-L-beta; oxidoreductin-1-L-beta; endoplasmic oxidoreductin-1-like protein B; endoplasmic reticulum oxidoreductin-1-like protein B; ERO1-like beta (S. cerevisiae); Endoplasmic reticulum oxidoreductin-1-like protein B; Oxidoreductin-1-L-beta
products gene name :
ERO1LB
other gene names :
ERO1LB; ERO1LB; ERO1-L-beta
uniprot entry name :
ERO1B_HUMAN
storage stability :
Store all reagents at 2-8 degree C
ncbi acc num :
NP_063944.3
ncbi gb acc num :
NM_019891.3
ncbi mol weight :
53,543 Da
ncbi pathways :
Insulin Processing Pathway (105903); Metabolism Of Proteins Pathway (106230); Peptide Hormone Metabolism Pathway (771603); Protein Processing In Endoplasmic Reticulum Pathway (167325); Protein Processing In Endoplasmic Reticulum Pathway (167190)
uniprot summary :
ERO1LB: Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. Required for the folding of cell, thereby being a source of oxidative stress. Belongs to the EROs family. Protein type: Endoplasmic reticulum; EC 1.8.4.-; Oxidoreductase. Chromosomal Location of Human Ortholog: 1q42.2-q43. Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum. Molecular Function: protein binding; unfolded protein binding; protein disulfide isomerase activity; protein disulfide oxidoreductase activity; oxidoreductase activity; oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor. Biological Process: insulin processing; extracellular matrix organization and biogenesis; protein maturation via protein folding; 4-hydroxyproline metabolic process; protein folding; cell redox homeostasis; glucose homeostasis