catalog number :
MBS9327342
products type :
ELISA Kit
products full name :
Human Dyslexia-associated protein KIAA0319, KIAA0319 ELISA Kit
products short name :
[KIAA0319]
products name syn :
[Human Dyslexia-associated protein KIAA0319 (KIAA0319) ELISA kit; DLX2; DYLX2; DYX2; MGC176717; dyslexia susceptibility 2; KIAA0319]
other names :
[dyslexia-associated protein KIAA0319 isoform b; Dyslexia-associated protein KIAA0319; dyslexia-associated protein KIAA0319; neuronal migration; dyslexia susceptibility 2; KIAA0319]
products gene name :
[KIAA0319]
other gene names :
[KIAA0319; KIAA0319; DYX2; NMIG; DYLX2]
uniprot entry name :
K0319_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of KIAA0319 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_001161846.1
ncbi gb acc num :
NM_001168374.1
ncbi mol weight :
117,763 Da
ncbi summary :
This gene encodes a transmembrane protein that contains a large extracellular domain with multiple polycystic kidney disease (PKD) domains. The encoded protein may play a role in the development of the cerebral cortex by regulating neuronal migration and cell adhesion. Single nucleotide polymorphisms in this gene are associated with dyslexia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
uniprot summary :
KIAA0319: Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non- cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites. Defects in KIAA0319 may be a cause of susceptibility to dyslexia type 2 (DYX2); also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability. A lower expression is associated with the risk haplotype. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 6p22.3. Cellular Component: early endosome membrane; early endosome; plasma membrane; integral to membrane. Molecular Function: protein binding. Biological Process: neuron migration. Disease: Dyslexia, Susceptibility To, 2
size4 :
10x96-Strip-Wells