Human Mitogen-activated protein kinase kinase kinase 12, MAP3K12 ELISA Kit | MyBioSource MBS9326823 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Mitogen-activated protein kinase kinase kinase 12, MAP3K12 ELISA Kit

catalog :

MBS9326823

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9326823

products type :

ELISA Kit

products full name :

Human Mitogen-activated protein kinase kinase kinase 12, MAP3K12 ELISA Kit

products short name :

[mitogen-activated protein kinase kinase kinase 12]

products name syn :

[Human Mitogen-activated protein kinase kinase kinase 12 (MAP3K12) ELISA kit; DLK; MEKK12; MUK; ZPK; ZPKP1; dual leucine zipper kinase DLK; leucine zipper protein kinase; protein kinase MUK; zipper protein kinase; mitogen-activated protein kinase kinase kinase 12]

other names :

[mitogen-activated protein kinase kinase kinase 12 isoform 1; Mitogen-activated protein kinase kinase kinase 12; mitogen-activated protein kinase kinase kinase 12; protein kinase MUK; MAPK-upstream kinase; mixed lineage kinase; leucine zipper protein kinase; dual leucine zipper kinase DLK; dual leucine zipper bearing kinase; mitogen-activated protein kinase kinase kinase 12; Dual leucine zipper bearing kinase; DLK; Leucine-zipper protein kinase; ZPK; MAPK-upstream kinase; MUK; Mixed lineage kinase]

products gene name :

[MAP3K12]

other gene names :

[MAP3K12; MAP3K12; DLK; MUK; ZPK; ZPKP1; MEKK12; ZPK; DLK; ZPK; MUK]

uniprot entry name :

M3K12_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of MAP3K12 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

301898343

ncbi acc num :

NP_001180440.1

ncbi gb acc num :

NM_001193511.1

uniprot acc num :

Q12852

ncbi mol weight :

96,322 Da

ncbi pathways :

Insulin Signaling Pathway (198845); MAPK Cascade Pathway (198834); MAPK Signaling Pathway (198779); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); Regulation Of P38-alpha And P38-beta Pathway (137964)

ncbi summary :

This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]

uniprot summary :

DLK: May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Protein type: Protein kinase, TKL; Kinase, protein; EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; LZK subfamily. Chromosomal Location of Human Ortholog: 12q13. Cellular Component: growth cone; membrane; axon; cytoplasm; plasma membrane; cytosol. Molecular Function: protein serine/threonine kinase activity; protein binding; protein homodimerization activity; MAP kinase kinase kinase activity; protein kinase binding; ATP binding; protein kinase activity. Biological Process: peptidyl-serine phosphorylation; activation of MAPKK activity; histone phosphorylation; protein amino acid autophosphorylation; peptidyl-threonine phosphorylation; JNK cascade; protein amino acid phosphorylation

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage