Rat Peptidyl-prolyl cis-trans isomerase FKBP1A, FKBP1A ELISA Kit | MyBioSource MBS9326780 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Rat Peptidyl-prolyl cis-trans isomerase FKBP1A, FKBP1A ELISA Kit

catalog :

MBS9326780

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9326780

products type :

ELISA Kit

products full name :

Rat Peptidyl-prolyl cis-trans isomerase FKBP1A, FKBP1A ELISA Kit

products short name :

[FK506 binding protein 1A, 12kDa]

products name syn :

[Rat Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) ELISA kit; RP11-314N13.2; FKBP-12; FKBP1; FKBP12; FKBP12C; PKC12; PKCI2; PPIASE; FK506 binding protein12; FK506-binding protein 1; FK506-binding protein 12; FK506-binding protein 1A (12kD) ; FK506-binding protein; ; FK506 binding protein 1A; 12kDa]

other names :

[peptidyl-prolyl cis-trans isomerase FKBP1A; Peptidyl-prolyl cis-trans isomerase FKBP1A; peptidyl-prolyl cis-trans isomerase FKBP1A; 12 kDa FKBP; calstabin-1; PPIase FKBP1A; binding protein; Immunophilin FKBP12; FK506-binding protein 1A; 12 kDa FK506-binding protein; 12 kDa FK506-binding protein; 12 kDa FKBP; FKBP-12; Calstabin-1; FK506-binding protein 1A; FKBP-1A; Immunophilin FKBP12; Rotamase]

products gene name :

[FKBP1A]

other gene names :

[FKBP1A; FKBP1A; FKBP1; FKBP12; FKBP-12; FKBP-1A; Rotamase; FKBP1; FKBP12; PPIase FKBP1A; 12 kDa FKBP; FKBP-12; FKBP-1A]

uniprot entry name :

FKB1A_RABIT

reactivity :

Rat

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Assay Type: Quantitative Sandwich. Detection Range: 62.5 pg/ml - 2000 pg/ml. Sensitivity: 10 pg/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of FKBP1A (hereafter termed "analyte") in undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

283837823

ncbi acc num :

NP_001164597.1

ncbi gb acc num :

NM_001171126.1

uniprot acc num :

P62943

ncbi mol weight :

11,951 Da

uniprot summary :

FKBP12: an immunophilin and peptidyl-prolyl cis-trans isomerase that binds to the immunosuppressant drugs FK506 (a.k.a. tacrolimus or Fujimycin) and rapamycin (a.k.a. Sirolimus). The FKBP12/rapamycin complex binds NFAT transcription factors and inhibits the induction of T cell genes including IL-2, IL-3, IL-4, TNF-alpha and GM-CSF. FK506 is used in treating patients after organ transplant and those suffering from autoimmune disorders. The immunosuppressant activity of FKBP12 is not apparently related to its prolyl isomerase activity. The FKBP12/rapamycin complex inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding the mTOR Complex1 (mTORC1). mTORC1 contains Raptor, mLST8, and PRAS40, and interacts with DEPTOR, which inhibits its activity. mTOR, a S/T protein kinase, is a central regulator of cellular growth and metabolism. Its inhibition enhances the dependence on aerobic glycolysis in leukemic cells. Protein type: EC 5.2.1.8; Isomerase. Chromosomal Location of Human Ortholog: 20p13. Cellular Component: endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; membrane; cytoplasm; nerve terminal; Z disc; cytosol. Molecular Function: protein binding; signal transducer activity; enzyme binding; protein homodimerization activity; FK506 binding; peptidyl-prolyl cis-trans isomerase activity; activin binding; macrolide binding; calcium channel inhibitor activity; Hsp70 protein binding; SMAD binding; transforming growth factor beta receptor binding. Biological Process: heart morphogenesis; protein maturation via protein folding; protein peptidyl-prolyl isomerization; T cell activation; positive regulation of protein binding; protein folding; response to caffeine; T cell proliferation; regulation of protein localization; muscle contraction; negative regulation of protein amino acid phosphorylation; negative regulation of release of sequestered calcium ion into cytosol; transforming growth factor beta receptor signaling pathway; fibril organization and biogenesis; ventricular cardiac muscle morphogenesis; protein refolding; response to iron ion; regulation of immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; cytokine and chemokine mediated signaling pathway; regulation of activin receptor signaling pathway; SMAD protein complex assembly; negative regulation of protein phosphatase type 2B activity; de novo protein folding; positive regulation of protein ubiquitination; release of sequestered calcium ion into cytosol

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage