catalog number :
MBS9326757
products type :
ELISA Kit
products full name :
Mouse Mixed lineage kinase domain-like protein, MLKL ELISA Kit
products short name :
[mixed lineage kinase domain-like]
products name syn :
[Mouse Mixed lineage kinase domain-like protein (MLKL) ELISA kit; FLJ34389; ; mixed lineage kinase domain-like]
other names :
[mixed lineage kinase domain-like protein; Mixed lineage kinase domain-like protein; mixed lineage kinase domain-like protein; mixed lineage kinase domain-like]
products gene name :
[MLKL]
other gene names :
[Mlkl; Mlkl; 9130019I15Rik]
uniprot entry name :
MLKL_MOUSE
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Human Body Fluids And Tissue Homogenates. Assay Type: Quantitative Sandwich. Detection Range: 62.5pg/ml-2000pg/ml. Sensitivity: 10pg/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determine the level of MLKL (hereafter termed "analyte") in undiluted original Human body fluids and tissue homogenates. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_083281.1
ncbi gb acc num :
NM_029005.2
ncbi mol weight :
53,375 Da
ncbi summary :
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
uniprot summary :
MLKL: Belongs to the protein kinase superfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, TKL; TKL group; TKL-Unique family. Cellular Component: membrane; cytoplasm; plasma membrane. Molecular Function: transferase activity, transferring phosphorus-containing groups; protein complex binding; nucleotide binding; protein kinase binding; ATP binding; protein kinase activity. Biological Process: programmed cell death; protein amino acid phosphorylation
size4 :
10x96-Strip-Wells