catalog number :
MBS9326632
products type :
ELISA Kit
products full name :
Human Growth arrest-specific protein 2, GAS2 ELISA Kit
products short name :
[growth arrest-specific 2]
products name syn :
[Human Growth arrest-specific protein 2 (GAS2) ELISA kit; MGC32610; ; growth arrest-specific 2]
other names :
[growth arrest-specific protein 2; Growth arrest-specific protein 2; growth arrest-specific protein 2; GAS-2; growth arrest-specific 2]
products gene name :
[GAS2]
other gene names :
[GAS2; GAS2; GAS-2]
uniprot entry name :
GAS2_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Assay Type: Quantitative Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of GAS2 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_001137302.1
ncbi gb acc num :
NM_001143830.1
ncbi mol weight :
34,945 Da
ncbi pathways :
Apoptosis Pathway (105648); Apoptotic Cleavage Of Cellular Proteins Pathway (105678); Apoptotic Execution Phase Pathway (105677); Caspase Cascade In Apoptosis Pathway (137974); Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway (105679)
ncbi summary :
The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009]
uniprot summary :
GAS2: May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process. Belongs to the GAS2 family. Protein type: Motility/polarity/chemotaxis; Apoptosis. Chromosomal Location of Human Ortholog: 11p14.3. Cellular Component: membrane; actin filament; cytosol. Biological Process: regulation of cell shape; apoptosis; cell cycle arrest; cell structure disassembly during apoptosis
size4 :
10x96-Strip-Wells