Human Nuclear receptor subfamily 1 group I member 2, NR1I2 ELISA Kit | MyBioSource MBS9326391 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Nuclear receptor subfamily 1 group I member 2, NR1I2 ELISA Kit

catalog :

MBS9326391

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9326391

products type :

ELISA Kit

products full name :

Human Nuclear receptor subfamily 1 group I member 2, NR1I2 ELISA Kit

products short name :

[nuclear receptor subfamily 1, group I, member 2]

products name syn :

[Human Nuclear receptor subfamily 1 group I member 2 (NR1I2) ELISA kit; BXR; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; SAR; SXR; orphan nuclear receptor PXR; steroid and xenobiotic receptor; nuclear receptor subfamily 1; group I; member 2]

other names :

[nuclear receptor subfamily 1 group I member 2 isoform 1; Nuclear receptor subfamily 1 group I member 2; nuclear receptor subfamily 1 group I member 2; pregnane X receptor; orphan nuclear receptor PXR; orphan nuclear receptor PAR1; steroid and xenobiotic receptor; pregnane X nuclear receptor variant 2; nuclear receptor subfamily 1, group I, member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR]

products gene name :

[NR1I2]

other gene names :

[NR1I2; NR1I2; BXR; PAR; PRR; PXR; SAR; SXR; ONR1; PAR1; PAR2; PARq; PXR; SXR]

uniprot entry name :

NR1I2_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Mouse Body Fluids And Tissue Homogenates. Assay Type: Quantitative Sandwich. Detection Range: 0.625ng/m-20ng/ml. Sensitivity: 0.1ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determine the level of NQO2 (hereafter termed "analyte") in undiluted original Mouse body fluids and tissue homogenates. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

34398348

ncbi acc num :

NP_003880.3

ncbi gb acc num :

NM_003889.3

uniprot acc num :

O75469

ncbi mol weight :

49,762 Da

ncbi pathways :

Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Nuclear Receptor Transcription Pathway (105979); Nuclear Receptors Pathway (198848); Nuclear Receptors In Lipid Metabolism And Toxicity Pathway (198887)

ncbi summary :

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]

uniprot summary :

PXR: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. Heterodimer with RXR. Interacts with NCOA1. Expressed in liver, colon and small intestine. Belongs to the nuclear hormone receptor family. NR1 subfamily. 7 isoforms of the human protein are produced by alternative splicing. Protein type: Nuclear receptor; DNA-binding. Chromosomal Location of Human Ortholog: 3q12-q13.3. Cellular Component: nucleoplasm. Molecular Function: ligand-dependent nuclear receptor activity; protein binding; zinc ion binding; transcription coactivator activity; steroid hormone receptor activity; drug binding. Biological Process: steroid metabolic process; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; positive regulation of transcription, DNA-dependent; drug export; signal transduction; xenobiotic metabolic process; exogenous drug catabolic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; xenobiotic transport; steroid hormone mediated signaling; negative regulation of transcription, DNA-dependent

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage