catalog number :
MBS9326061
products type :
ELISA Kit
products full name :
Rabbit cluster of differentiation 34, CD34 ELISA Kit
products short name :
cluster of differentiation 34 (CD34)
products name syn :
Rabbit cluster of differentiation 34 (CD34) ELISA Kit; RP11-328D5.2; CD34 antigen; hematopoietic progenitor cell antigen CD34; cluster of differentiation 34 (CD34)
other names :
CD34; CD34 antigen; hematopoietic progenitor cell antigen CD34; CD34 antigen; CD34 molecule; CD34 antigen
products gene name :
CD34
other gene names :
CD34; CD34
uniprot entry name :
Q3C1E7_HUMAN
storage stability :
Store all reagents at 2-8 degree C
ncbi acc num :
AAB25223.1
ncbi mol weight :
35,087 Da
ncbi pathways :
Adaptive Immune System Pathway (366160); C-MYB Transcription Factor Network Pathway (138073); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Immune System Pathway (106386); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (106413)
ncbi summary :
The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
uniprot summary :
CD34: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. Belongs to the CD34 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell surface; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: intercellular bridge; perinuclear region of cytoplasm; integral to plasma membrane; lysosome; apical plasma membrane; cytoplasm; basal plasma membrane; plasma membrane; external side of plasma membrane. Molecular Function: sulfate binding; carbohydrate binding; transcription factor binding. Biological Process: positive regulation of odontogenesis; regulation of immune response; negative regulation of nitric oxide biosynthetic process; glomerular filtration; cell motility involved in cell locomotion; negative regulation of blood coagulation; negative regulation of tumor necrosis factor production; signal transduction; positive regulation of interleukin-10 production; cell proliferation; cell-cell adhesion; positive regulation of angiogenesis; endothelial cell proliferation; regulation of blood pressure; tissue homeostasis; hemopoiesis; leukocyte migration