Human Vacuolar protein sorting-associated protein 4B, VPS4B ELISA Kit | MyBioSource MBS9326031 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Vacuolar protein sorting-associated protein 4B, VPS4B ELISA Kit

catalog :

MBS9326031

quantity :

48-Strip-Wells

price :

435 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9326031

products type :

ELISA Kit

products full name :

Human Vacuolar protein sorting-associated protein 4B, VPS4B ELISA Kit

products short name :

vacuolar protein sorting 4 homolog B (S. cerevisiae)

products name syn :

Human Vacuolar protein sorting-associated protein 4B (VPS4B) ELISA kit; MIG1; SKD1; SKD1B; VPS4-2; cell migration-inducing 1; suppressor of K+ transport defect 1; vacuolar protein sorting 4B; vacuolar protein sorting factor 4B; vacuolar protein sorting 4 homolog B (S. cerevisiae)

other names :

vacuolar protein sorting-associated protein 4B; Vacuolar protein sorting-associated protein 4B; vacuolar protein sorting-associated protein 4B; cell migration-inducing 1; vacuolar protein sorting 4B; suppressor of K+ transport defect 1; cell migration-inducing gene 1 protein; suppressor of K(+) transport growth defect 1; vacuolar protein sorting 4 homolog B (S. cerevisiae); Cell migration-inducing gene 1 protein; Suppressor of K(+) transport growth defect 1; Protein SKD1

products gene name :

VPS4B

other gene names :

VPS4B; VPS4B; MIG1; SKD1; SKD1B; VPS4-2; SKD1; VPS42; MIG1; Protein SKD1

uniprot entry name :

VPS4B_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 31.2 pg/ml - 1000 pg/ml. Sensitivity: 5.0 pg/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of VPS4B (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

17865802

ncbi acc num :

NP_004860.2

ncbi gb acc num :

NM_004869.3

uniprot acc num :

O75351

ncbi mol weight :

49,302 Da

ncbi pathways :

CXCR4-mediated Signaling Events Pathway (137910); Endocytosis Pathway (102279); Endocytosis Pathway (102181); Endosomal Sorting Complex Required For Transport (ESCRT) Pathway (205244); Membrane Trafficking Pathway (106160)

ncbi summary :

The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16. [provided by RefSeq, Jul 2008]

uniprot summary :

VPS4B: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Belongs to the AAA ATPase family. Protein type: EC 3.6.4.6; Vesicle. Chromosomal Location of Human Ortholog: 18q21.33. Cellular Component: spindle pole; centrosome; late endosome membrane; lysosome; early endosome; cytoplasm; late endosome; vacuolar membrane; endosome membrane; nucleus; cytosol; endosome. Molecular Function: protein C-terminus binding; protein binding; ATPase activity; ATPase activity, coupled; microtubule-severing ATPase activity; ATP binding. Biological Process: viral reproduction; cell separation during cytokinesis; endosome organization and biogenesis; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; regulation of viral reproduction; intracellular cholesterol transport; viral infectious cycle; protein depolymerization; endosome transport; response to lipid; mitotic metaphase plate congression; endosome to lysosome transport via multivesicular body sorting pathway; cytoplasmic microtubule organization and biogenesis; protein transport; potassium ion transport; nuclear organization and biogenesis; vacuole organization and biogenesis

size1 :

48-Strip-Wells

price1 :

435 USD

size2 :

96-Strip-Wells

price2 :

600

more info or order :

MyBioSource product webpage