product summary
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company name :
MyBioSource
product type :
ELISA/assay
product name :
Human Rab5 GDP/GTP exchange factor, RABGEF1 ELISA Kit
catalog :
MBS9325962
quantity :
48-Strip-Wells
price :
470 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS9325962
products type :
ELISA Kit
products full name :
Human Rab5 GDP/GTP exchange factor, RABGEF1 ELISA Kit
products short name :
[RAB guanine nucleotide exchange factor (GEF) 1]
products name syn :
[Human Rab5 GDP/GTP exchange factor (RABGEF1) ELISA kit; FLJ32302; RABEX5; rabex-5; OTTHUMP00000210543; Rab5 GDP/GTP exchange factor; RAB guanine nucleotide exchange factor (GEF) 1]
other names :
[rab5 GDP/GTP exchange factor isoform a; Rab5 GDP/GTP exchange factor; rab5 GDP/GTP exchange factor; rabaptin-5-associated exchange factor for Rab5; RAB guanine nucleotide exchange factor (GEF) 1; RAP1; Rabaptin-5-associated exchange factor for Rab5; Rabex-5]
products gene name :
[RABGEF1]
other gene names :
[RABGEF1; RABGEF1; RAP1; RABEX5; rabex-5; RABEX5]
uniprot entry name :
RABX5_HUMAN
reactivity :
Human
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Assay Type: Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of RABGEF1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi gi num :
559098403
ncbi acc num :
NP_001273989.1
ncbi gb acc num :
NM_001287060.1
uniprot acc num :
Q9UJ41
ncbi mol weight :
79,371 Da
ncbi summary :
RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010]
uniprot summary :
RABGEF1: Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase. Interacts with RGS14; the interaction is GTP-dependent. Heterodimer with RABEP1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Interacts with RAB21, and with 100-fold lower affinity also with RAB22. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2. Interacts with ubiquitinated EGFR. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; GAPs, Rab. Chromosomal Location of Human Ortholog: 7q11.21. Cellular Component: recycling endosome; early endosome; vesicle. Molecular Function: protein binding; DNA binding; zinc ion binding; ubiquitin-protein ligase activity; Rab guanyl-nucleotide exchange factor activity; Rab GTPase binding. Biological Process: negative regulation of protein amino acid phosphorylation; negative regulation of mast cell degranulation; negative regulation of inflammatory response; protein ubiquitination; negative regulation of Ras protein signal transduction; negative regulation of receptor-mediated endocytosis; endocytosis; protein targeting to membrane; negative regulation of leukocyte migration
size1 :
48-Strip-Wells
price1 :
470 USD
size2 :
96-Strip-Wells
price2 :
680
size3 :
5x96-Strip-Wells
price3 :
3100
size4 :
10x96-Strip-Wells
price4 :
6095
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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