catalog number :
MBS9325925
products type :
ELISA Kit
products full name :
Mouse Dynamin-like 120 kDa protein, mitochondrial, OPA1 ELISA Kit
products short name :
[optic atrophy 1 (autosomal dominant)]
products name syn :
[Mouse Dynamin-like 120 kDa protein; mitochondrial (OPA1) ELISA kit; FLJ12460; KIAA0567; MGM1; NPG; NTG; largeG; mitochondrial dynamin-like GTPase; optic atrophy 1; optic atrophy 1 (autosomal dominant)]
other names :
[dynamin-like 120 kDa protein, mitochondrial isoform 2; Dynamin-like 120 kDa protein, mitochondrial; Large GTP-binding protein; LargeG; Optic atrophy protein 1 homologCleaved into the following chain:Dynamin-like 120 kDa protein, form S1]
products gene name :
[OPA1]
other gene names :
[Opa1; LargeG]
uniprot entry name :
OPA1_MOUSE
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 0.5 ng/ml - 16 ng/mL. Sensitivity: 0.1 ng/mL
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of OPA1 (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_598513.1
ncbi gb acc num :
NM_133752.3
ncbi mol weight :
111,339 Da
uniprot summary :
OPA1: a dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space. Defects in OPA1 are the cause of optic atrophy 1 and deafness. Eight splice-variant isoforms have been described. Protein type: Mitochondrial; Apoptosis; Membrane protein, integral; Hydrolase; EC 3.6.5.5. Cellular Component: nucleoplasm; mitochondrial crista; mitochondrial outer membrane; membrane; mitochondrion; cytoplasm; mitochondrial inner membrane; dendrite; integral to membrane; mitochondrial intermembrane space. Molecular Function: GTPase activity; protein binding; GTP binding; hydrolase activity; nucleotide binding. Biological Process: inner mitochondrial membrane organization and biogenesis; positive regulation of neuron maturation; mitochondrion organization and biogenesis; mitochondrial genome maintenance; visual perception; mitochondrial fusion; apoptosis; response to stimulus; neural tube closure
size4 :
10x96-Strip-Wells