ELISA/assay

Human RAC-gamma serine/threonine-protein kinase, AKT3 ELISA Kit

MBS9325789

96 Strip Wells

600 USD

ELISA Kit

Human RAC-gamma serine/threonine-protein kinase, AKT3 ELISA Kit

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

Human RAC-gamma serine/threonine-protein kinase (AKT3) ELISA kit; DKFZp434N0250; PKB-GAMMA; PKBG; PRKBG; RAC-PK-gamma; RAC-gamma; STK-2; AKT3 kinase; OTTHUMP00000037911; OTTHUMP00000037912; RAC-gamma serine/threonine protein kinase; protein kinase B gamma; serine threo; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B; gamma)

RAC-gamma serine/threonine-protein kinase isoform 2; RAC-gamma serine/threonine-protein kinase; RAC-gamma serine/threonine-protein kinase; PKB gamma; RAC-gamma serine/threonine protein kinase; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); v-akt murine thymoma viral oncogene homolog 3; Protein kinase Akt-3; Protein kinase B gamma; PKB gamma; RAC-PK-gamma; STK-2

AKT3

AKT3; AKT3; MPPH; PKBG; MPPH2; PRKBG; STK-2; PKB-GAMMA; RAC-gamma; RAC-PK-gamma; PKBG; PKB gamma

AKT3_HUMAN

Human

332078559

NP_001193658.1

NM_001206729.1

Q9Y243

55,775 Da

AKT Phosphorylates Targets In The Cytosol Pathway 106475!!AKT Phosphorylates Targets In The Nucleus Pathway 106476!!AKT-mediated Inactivation Of FOXO1A Pathway 106333!!Acute Myeloid Leukemia Pathway 83117!!Acute Myeloid Leukemia Pathway 529!!Adaptive Immune System Pathway 366160!!Adipocytokine Signaling Pathway 83093!!Adipocytokine Signaling Pathway 505!!Apoptosis Pathway 83060!!Apoptosis Pathway 470

The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Function: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.2 PublicationsManual assertion based on experiment in:Ref.18. Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Enzyme regulation: Two specific sites, one in the kinase domain (Thr-305) and the other in the C-terminal regulatory region (Ser-472), need to be phosphorylated for its full activation IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival.

96 Strip Wells

600 USD