Human Mitogen-activated protein kinase kinase kinase 8, MAP3K8 ELISA Kit | MyBioSource MBS9325582 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Mitogen-activated protein kinase kinase kinase 8, MAP3K8 ELISA Kit

catalog :

MBS9325582

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9325582

products type :

ELISA Kit

products full name :

Human Mitogen-activated protein kinase kinase kinase 8, MAP3K8 ELISA Kit

products short name :

[mitogen-activated protein kinase kinase kinase 8]

products name syn :

[Human Mitogen-activated protein kinase kinase kinase 8 (MAP3K8) ELISA kit; RP11-449I17.8; COT; EST; ESTF; FLJ10486; MEKK8; TPL2; Tpl-2; c-COT; Cancer Osaka thyroid oncogene; Ewing sarcoma transformant; OTTHUMP00000019392; OTTHUMP00000019393; cot (cancer Osaka thyroid) oncogene; mitogen-activated protein kinase kinase kinase 8]

other names :

[mitogen-activated protein kinase kinase kinase 8; Mitogen-activated protein kinase kinase kinase 8; mitogen-activated protein kinase kinase kinase 8; proto-oncogene c-Cot; tumor progression locus 2; Ewing sarcoma transformant; cot (cancer Osaka thyroid) oncogene; proto-oncogene serine/threoine protein kinase; mitogen-activated protein kinase kinase kinase 8; Cancer Osaka thyroid oncogene; Proto-oncogene c-Cot; Serine/threonine-protein kinase cot; Tumor progression locus 2; TPL-2]

products gene name :

[MAP3K8]

other gene names :

[MAP3K8; MAP3K8; COT; EST; ESTF; TPL2; MEKK8; Tpl-2; c-COT; COT; ESTF; TPL-2]

uniprot entry name :

M3K8_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Assay Type: Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: 1.0 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of MAPK8 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

346644795

ncbi acc num :

NP_001231063.1

ncbi gb acc num :

NM_001244134.1

uniprot acc num :

P41279

ncbi mol weight :

52,925 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); CD28 Co-stimulation Pathway (119553); CD28 Dependent PI3K/Akt Signaling Pathway (119554); Costimulation By The CD28 Family Pathway (119552); Cytokine Signaling In Immune System Pathway (366171); Immune System Pathway (106386); Insulin Signaling Pathway (198845); Interleukin-1 Signaling Pathway (160141); JNK Signaling In The CD4+ TCR Pathway (138066); MAPK Signaling Pathway (198779)

ncbi summary :

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

uniprot summary :

Cot: an oncogenic Ser/Thr kinase of the STE group. Activates IkappaB kinases, thus inducing the nuclear translocation of NF-kappaB. Promotes the production of TNF-alpha and IL-2 during T lymphocyte activation. Interacts with NFkB-p105. Overexpressed and amplified in breast tumors. Viral insertions induce rat lymphomas and mouse mammary carcinomas. Isolated as a transforming factor in two cell lines. Mediates LPS activation of macrophages. 2 isoforms of the human protein are produced by alternative initiation. Protein type: Protein kinase, STE; EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); Oncoprotein; Kinase, protein; STE group; STE-Unique family. Chromosomal Location of Human Ortholog: 10p11.23. Cellular Component: cytoplasm; cytosol. Molecular Function: protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; magnesium ion binding; ATP binding; receptor signaling protein serine/threonine kinase activity. Biological Process: activation of MAPKK activity; apoptosis; regulation of cell differentiation; T cell costimulation; MAPKKK cascade; cell cycle; protein amino acid phosphorylation. Disease: Lung Cancer

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage